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A chronic ethanol-feeding study in rhesus monkeys

  • Metabolic Dysfunction
  • Published:
Lipids

Abstract

This study describes the effect of chronic ethanol-feeding in rhesus monkeys. Animals which were maintained on a diet containing 18:2n-6 and 18:3n-3 as 1.4 and 0.08% of the calories, respectively, and consumed alcohol (mean 2.6 g kg−1 d−1) had decreased amounts of 20:4n-6 and 22:6n-3 in their livers and plasma lipids compared with controls. Alcohol consumption did not appear to effect the absorption of2H5-18:2n-6 and 18:3n-3 esters into the blood following an oral dose. There was an increase in2H5 enrichment in plasma 20:4n-6 and 22:6n-3, indicating that alcohol may have increased production of these fatty acids. There was a greater concentration of 4-hydroxynonenal in the plasma of alcohol-exposed monkeys compared to controls.

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Abbreviations

FA:

fatty acid

PUFA:

polyunsaturated fatty acid

References

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Author information

Authors and Affiliations

  1. U.S. Department of Agriculture, Human Nutrition Research Center, Beltsville, Maryland

    Robert J. Pawlosky

  2. National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, 20852, Rockville, Maryland

    Norman Salem Jr.

Authors
  1. Robert J. Pawlosky
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  2. Norman Salem Jr.
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Corresponding author

Correspondence to Robert J. Pawlosky.

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Cite this article

Pawlosky, R.J., Salem, N. A chronic ethanol-feeding study in rhesus monkeys. Lipids 34 (Suppl 1), S131–S132 (1999). https://doi.org/10.1007/BF02562261

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  • DOI: https://doi.org/10.1007/BF02562261

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