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Interferon-α therapy for multiple hemangiomas associated with coarctation of the aorta

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Summary

We report a rare combination of multiple hemangiomas and coarctation of the aorta in a 2-monthold female infant who responded to interferon-α (IFN-α) therapy. The coarctation was repaired successfully with the use of an artificial graft. In patients with symptomatic hemangiomas that do not respond to steroid therapy, IFN-α therapy should be considered.

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References

  1. White CW (1990) Treatment of hemagiomatosis with recobinant interferon alfa. Semin Hematol 27 (Suppl 4):15–22

    PubMed  CAS  Google Scholar 

  2. Schneeweiss A, Blieden LC, Shem-Tov A, Motro M, Feigel A, Neufeld HN (1982) Coarctation of the aorta with congenital hemangioma of the face and neck and aneurysm or dilatation of a subclavian or innominate artery. Chest 82:186–187

    PubMed  CAS  Google Scholar 

  3. Vaillant L, Lorette G, Chantepie A, Marchand M, Alison D, Vaillant MA, Laugier J (1988) Multiple cutaneous hemangiomas and coarctation of the aorta with right aortic arch. Pediatrics 81:707–710

    PubMed  CAS  Google Scholar 

  4. Burns AJ, Kaplan LC, Mulliken JB (1991) Is there an association between hemangioma and syndromes with dysmorphic features? Pediatrics 88:1257–1267

    PubMed  CAS  Google Scholar 

  5. Tunnessen WW Jr (1994) Pediatric dermatology. In: Oski FA, DeAngelis CD, Feigin RD, Warshaw JB (eds) Principles and practice of pediatrics. Lippincott Philadelphia, pp 908–911

    Google Scholar 

  6. Honey M, Lincoln CR, Osborne MP, de Bono DP (1975) Coarctation of aorta with right aortic arch. Report of surgical correction in two cases: one with associated anomalous origin of left circumflex coronary artery from the right pulmonary artery. Br Heart J 37:937–945

    PubMed  CAS  Google Scholar 

  7. Kasabach HH, Merritt KK (1940) Capillary hemangioma with extensive purpura: Report of a case. Am J Dis Child 59:1063–1070

    Google Scholar 

  8. White CW, Wolf SJ, Korones DN, Sondheimer HM, Tosi MF, Yu A (1991) Treatment of childhood angiomatous diseases with recombinant interferon alfa-2a. J Pediatr 118:59–66

    Article  PubMed  CAS  Google Scholar 

  9. Ezekowitz RAB, Mulliken JB, Folkman J (1992) Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326:1456–1463

    Article  PubMed  CAS  Google Scholar 

  10. Enjolras O, Riche MC, Merland JJ, Escande JP (1990) Management of alarming hemangiomas in infancy: A review of 25 cases. Pediatrics 85:491–498

    PubMed  CAS  Google Scholar 

  11. Mulliken JB, Zetter BR, Folkman J (1982) In vitro characteristics of endothelium from hemangiomas and vascular malformations. Surgery 92:348–353

    PubMed  CAS  Google Scholar 

  12. Heyns AdP, Eldor A, Vlodavsky I, Kaiser N, Fridman R, Panet A (1985) The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events: Studies with vascular smooth muscle cells and endothelial cells. Exp Cell Res 161:297–306.

    Article  PubMed  CAS  Google Scholar 

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Hijii, T., Fukushige, J., Tasaki, K. et al. Interferon-α therapy for multiple hemangiomas associated with coarctation of the aorta. Heart Vessels 11, 211–214 (1996). https://doi.org/10.1007/BF02559994

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  • DOI: https://doi.org/10.1007/BF02559994

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