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Flow patterns in dog aortic arch under a steady flow condition simulating mid-systole

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Summary

To elucidate the possible connection between blood flow and localized pathogenesis and the development of atherosclerosis in humans, we studied the flow patterns and the distribution of fluid axial velocity and wall shear stress in the aortic arch in detail. This was done by means of flow visualization and highspeed cinemicrographic techniques, using transparent aortic trees prepared from the dog. Under a steady flow condition at inflow Reynolds numbers of 700–1600, which simulated physiologic conditions at early- to midsystole, slow, spiral secondary, and recirculation flows formed along the left anterior wall of the aortic arch and at the entrance of each side branch adjacent to the vessel wall opposite the flow divider, respectively. The flow in the aortic arch consisted of three major components, namely, an undisturbed parallel flow located close to the common median plane of the arched aorta and its side branches, a clockwise rotational flow formed along the left ventral wall, and the main flow to the side branches, located along the right dorsal wall of the ascending aorta. Thus, looking down the aorta from its origin, the flow in the aortic arch appeared as a single helical flow revolving in a clockwise direction. Regions of low wall shear stress were located along the leading edge of each side branch opposite the flow divider where slow recirculation flow formed, and along the left ventral wall where slow spiral secondary flows formed. If we assume that the flow patterns in the human aortic arch well resemble those observed in the dog, then it is likely that atherosclerotic lesions develop preferentially at these sites of low wall shear stress in the same manner as in human coronary and cerebral arteries.

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References

  1. Wesolowski SA, Fries CC, Sabini AM, Sawyer PN (1965) The significance of turbulence in hemic systems and in the distribution of the atherosclerotic lesion. Surgery 57:155–162.

    PubMed  CAS  Google Scholar 

  2. Roach MR (1977) The effects of bifurcations and stenoses on arterial disease. In: Hwang NHC, Normann NA (eds) Cardiovascular flow dynamics and measurements. University Park Press, Baltimore, MD, pp 489–539.

    Google Scholar 

  3. DeBakey ME, Lawrie GM, Glaeser DH (1985) Patterns of atherosclerosis and their surgical significance. Ann Surg 201:115–131.

    Article  PubMed  CAS  Google Scholar 

  4. Schwartz CJ, Mitchell A Jr (1962) Observation on localization of arterial plaques. Circ Res 11:63–73.

    PubMed  CAS  Google Scholar 

  5. Meyer WW, Kauffman SL, Hardy-Stashin J (1980) Studies on the human aortic bifurcation: Part 2. Predilection sites of early lipid deposits in relation to preformed arterial structures. Atherosclerosis 37:389–397.

    Article  PubMed  CAS  Google Scholar 

  6. Svindland A, Walloe L (1985) Distribution pattern of sudanophilic plaques in the descending thoracic and proximal abdominal human aorta. Atherosclerosis 57: 219–224.

    Article  PubMed  CAS  Google Scholar 

  7. Cornhill JF, Herderick EE, Stary HC (1990) Topography of human aortic sudanophilic lesions. In: Liepsch DW (ed) Blood flow in large arteries: Applications to atherogenesis and clinical medicine. Monograph of Atherosclerosis, vol 15. Karger, Basel, pp 13–19.

    Google Scholar 

  8. Ishii T, Malcom GT, Osaka T, Masuda S, Asuwa N, Guzman MA, Shimada K, Strong JP (1990) Variation with age and serum cholesterol level in the topographic distribution of macroscopic aortic atherosclerotic lesions as assessed by image anaysis methods. Mod Pathol 3:713–719.

    PubMed  CAS  Google Scholar 

  9. Murphy EA, Rowsell HC, Downie HG, Robinson GA, Mustard JF (1962) Encrustation and atherosclerosis: The analogy between early in vivo lesions and deposits which occur in extracorporeal circulation. Canad Med Assoc J 87:259–274.

    PubMed  CAS  Google Scholar 

  10. Flaherty JT, Ferrans VJ, Pierce JE, Carew TE, Fry DL (1972) Localizing factors in experimental atherosclerosis. In: Likoff W, Segal BL, Insull W, Moyer JH (eds). Atherosclerosis and coronary heart disease. Grune and Stratton, New York, pp 40–83.

    Google Scholar 

  11. Rodkiewicz CM (1975) Localization of early atheroscserotic lesions in the arotic arch in the light of fluid flow. J Biomech 8:149–156.

    Article  PubMed  CAS  Google Scholar 

  12. Cornhill JF, Roach MR (1976) A quantitative study of the localization of atherosclerotic lesions in the rabbit aorta. Atherosclerosis 23:489–501.

    Article  PubMed  CAS  Google Scholar 

  13. Klimes F (1974) Research into flow on a model of the aorta and on mechanical systems for the assistance of the heart. Rev Czechoslovak Med 20:210–220.

    CAS  Google Scholar 

  14. Agrawal Y, Talbot L, Gong K (1978) Laser anemometer study of flow development in curved circular pipes. J Fluid Mech 85:497–518.

    Article  Google Scholar 

  15. Yearwood TL, Chandran KB (1980) Experimental investigation of steady flow through a model of the human aortic arch. J Biomech 13:1075–1088.

    Article  PubMed  CAS  Google Scholar 

  16. Rayman R, Kratky RG, Roach MR (1985) Steady flow visualization in a rigid canine aortic cast. J Biomech 18:863–875.

    Article  PubMed  CAS  Google Scholar 

  17. Rieu A, Friggi A, Pelissier R (1985) Velocity distribution along an elastic model of human arterial tree. J Biomech 18:703–715.

    Article  PubMed  CAS  Google Scholar 

  18. Frazin LJ, Lanza G, Vonesh M, Khasho F, Spitzzeri C, McGee S, Mehlman D, Chandran KB, Talano J. McPherson D (1990) Functional chiral asymmetry in descending thoracic arota. Circulation 82:1985–1993.

    PubMed  CAS  Google Scholar 

  19. Rogers WH, Rukskul A, Camishion RC, Padula RT (1971) in vivo cinephotographic analysis of aortic and major arterial flow pattens. Arch Surg 103:93–95.

    PubMed  CAS  Google Scholar 

  20. Seed WA, Wood NB (1971) Velocity patterns in the aorta. Cardiovasc. Res 5:319–330.

    PubMed  CAS  Google Scholar 

  21. Nerem RM, Rumberger JA Jr, Gross DR, Hamlin RL, Geiger GL (1974) Hot-film anemometer velocity measurements of arterial blood flow in horses. Circ Res 34:193–203.

    PubMed  CAS  Google Scholar 

  22. Farthing S, Peronneau P (1979) Flow in the thoracic aorta. Cardiovasc. Res 13:607–620.

    Article  PubMed  CAS  Google Scholar 

  23. Paulsen PK, Hasenkam JM (1983) Three-dimensional visualization of velocity profiles in the ascending aorta in dogs measured with a hot-film anemometer. J Biomech 16:201–210.

    Article  PubMed  CAS  Google Scholar 

  24. Fukushima T, Karino T, Goldsmith HL (1985) Disturbances of flow through transparent dog aortic arch. Heart Vessels 1:24–28.

    Article  PubMed  CAS  Google Scholar 

  25. Stein PD, Sabbah HN (1976) Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves. Circ Res 39:58–65.

    PubMed  CAS  Google Scholar 

  26. Nayler GL, Firmin DN, Longmore DB (1986) Blood flow imaging by cine magnetic resonance. J Comput Assist Tomogr 10:715–722.

    Article  PubMed  CAS  Google Scholar 

  27. Klipstein RH, Firmin DN, Underwood SR, Rees RSO, Longmore DB (1987) Blood flow patterns in the human aorta studied by magnetic resonance. Br Heart J 58:316–323.

    PubMed  CAS  Google Scholar 

  28. Segadal L, Matre K (1987) Blood velocity distribution in the human ascending aorta. Circulation 76:90–100.

    PubMed  CAS  Google Scholar 

  29. Karino T, Motomiya M (1983) Flow visualization in isolated transparent natural blood vessels. Biorheology 20:119–127.

    PubMed  CAS  Google Scholar 

  30. Nicholas WW, O'Rourke MF (1990) Turbulent blood flow and cardiovascular pathophysiology. In: Nichols WW, O'Rourke MF, (eds). Mc Donad's blood flow in arteries. Lea and Febiger, Philadelphia, pp 54–76.

    Google Scholar 

  31. Karino T, Kwong HM, Goldsmith HL (1979) Particle flow behavior in models of branching vessels. I. Vortices in 90° T-junctions. Biorheology 16:231–248.

    PubMed  CAS  Google Scholar 

  32. Karino T, Goldsmith HL (1985) Particle flow behavior in models of branching vessels. II. Effects of branching angle and diameter ratio on flow patterns. Biorheology 22:87–109

    PubMed  CAS  Google Scholar 

  33. Scarton HA, Shah PM, Tsapogas MJ (1977) Relationship of the spatial evolution of secondary flow in curved tubes to the aortic arch. In: Mechanics in engineering (American Society of Civil Engineers). University of Waterloo Press, Waterloo, pp 111–131

    Google Scholar 

  34. Schlichting H (1968) Boundary-Layer theory, 6th edn. McGraw Hill, New York, pp 589–590.

    Google Scholar 

  35. Asakura T, Karino T (1990) Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res 66:1045–1066.

    PubMed  CAS  Google Scholar 

  36. Ishibashi H, Sunamura M, Karino T (1995) Flow patterns and preferred sites of intimal thickening in end-to-end anastomosed vessels. Surgery 117:409–420.

    Article  PubMed  CAS  Google Scholar 

  37. Ku DN, Glagov S, Moore JE Jr, Zarins CK (1989) Flow patterns in the abdominal aorta under simulated postprandial and exercise conditions: An experimental study. J Vasc Surg 9:309–316.

    Article  PubMed  CAS  Google Scholar 

  38. Moore JE Jr, Ku DN (1994) Pulsatile velocity measurements in a model of the human abdominal aorta under resting conditions. J Biomech Eng 116:337–346

    PubMed  Google Scholar 

  39. Thomas JD (1990) Flow in the descending aorta: A turn of the screw of a sideways glance? Circulation 82:2263–2265.

    PubMed  CAS  Google Scholar 

  40. Flaherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK, Fry DL (1972) Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circ Res 30:23–33

    PubMed  CAS  Google Scholar 

  41. Langille BL, Adamson SL (1981) Relationship between blood flow direction and endothelial cell orientation at arterial branch sites in rabbits and mice. Circ Res 48:481–488.

    PubMed  CAS  Google Scholar 

  42. da Vinci L, quoted In: O'Malley C, Saunders J, eds) (1952) Leonardo da Vinci on the human body. Henry Schuman, New York, pp 258–274.

    Google Scholar 

  43. Bellhouse BJ, Talbot L (1969) The fluid mechanics of the aortic valve. J Fluid Mech 35:721–735.

    Article  Google Scholar 

  44. Lee CSF, Talbot L (1979) A fluid-mechanical study of the closure of heart valve. J Fluid Mech 91:41–63.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan

    Shunsuke Endo & Yasunori Sohara

  2. Research Institute for Electronic Science, Hokkaido University, North 12 West 6, North District, 060, Sapporo, Hokkaido, Japan

    Takeshi Karino

Authors
  1. Shunsuke Endo
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  2. Yasunori Sohara
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  3. Takeshi Karino
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Endo, S., Sohara, Y. & Karino, T. Flow patterns in dog aortic arch under a steady flow condition simulating mid-systole. Heart Vessels 11, 180–191 (1996). https://doi.org/10.1007/BF02559990

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  • DOI: https://doi.org/10.1007/BF02559990

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