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Logistic character of myocardial twitch force curve: Simulation

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Summary

We found that the isovolumic pressure-time curve of the canine left ventricle closely fitted the difference of two logistic function curves and that the isovolumic relaxation-pressure curve segment was more reliably characterized by a logistic time constant than by the conventional exponential time constant. We therefore hypothesized that the calcium (Ca) transient and the Ca-troponin (Tn) binding and crossbridge (CB) kinetics underlay the logistic character of the ventricular isovolumic pressure curve. We tested this hypothesis with a computer simulation of a simple Ca and CB kinetics model of myocardial isometric twitch force development. We assumed the isometric force curve (F) to be proportional to the instantaneous number of attached CBs that was theoretically given as the difference between the cumulative CB attachment and detachment curves. We radically changed the Ca transient, Ca-Tn binding, and CB kinetic parameters. We always found that both the cumulative CB attachment and detachment curves closely fitted logistic functions. The difference curve of these two best-fit logistic functions closely fitted the theoretical F curve with certain combinations of the Ca transient, the Ca-Tn binding, and the CB kinetic parameters. These results seem to support our hypothesis.

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Authors and Affiliations

  1. Department of Physiology II, Okayama University Medical School, 2-5-1 Shikata-cho, 700, Okayama, Japan

    Taisuke Sakamoto, Hiromi Matsubara, Yoshiki Hata, Juichiro Shimizu, Junichi Araki, Miyako Takaki & Hiroyuki Suga

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  1. Taisuke Sakamoto
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  2. Hiromi Matsubara
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  3. Yoshiki Hata
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  4. Juichiro Shimizu
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  5. Junichi Araki
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  6. Miyako Takaki
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  7. Hiroyuki Suga
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Sakamoto, T., Matsubara, H., Hata, Y. et al. Logistic character of myocardial twitch force curve: Simulation. Heart Vessels 11, 171–179 (1996). https://doi.org/10.1007/BF02559989

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  • DOI: https://doi.org/10.1007/BF02559989

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