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Omeprazole, a specific inhibitor of H+−K+-ATPase, inhibits bone resorptionin vitro

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Summary

Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+−K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.

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Authors and Affiliations

  1. Departments of Anatomy, University of Oulu, Kajaanintie 52, 90220, Oulu 22, Finland

    J. Tuukkanen

  2. Pathology, University of Oulu, Kajaanintie 52, 90220, Oulu 22, Finland

    H. K. Väänänen

Authors
  1. J. Tuukkanen
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  2. H. K. Väänänen
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This study was supported by grants from Aaltonen Foundation and Paulo Foundation, Finland.

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Tuukkanen, J., Väänänen, H.K. Omeprazole, a specific inhibitor of H+−K+-ATPase, inhibits bone resorptionin vitro . Calcif Tissue Int 38, 123–125 (1986). https://doi.org/10.1007/BF02556841

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  • DOI: https://doi.org/10.1007/BF02556841

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