Summary
We examined 17 patients with primary hyperparathyroidism for their serum 1,25 dihydroxyvitamin D levels and for their fractional intestinal calcium absorption rates using a whole body counter and calcium-47. As controls, 10 normal volunteers were examined both before and after administration of 1α-hydroxyvitamin D to increase serum 1,25 dihydroxyvitamin D. Values of serum 1,25 dihydroxyvitamin D were 71.6±37.6 pg/ml (mean ±SD) in patients with primary hyperparathyroidism and 75.3±27.7 pg/ml (mean ±SD) in normal volunteers after administration of 1α-hydroxyvitamin D, while values of intestinal calcium absorption rate were 61.5±16.5% (mean ±SD) in patients with primary hyperparathyroidism and 34.1±5.1% (mean ±SD) in normal controls, respectively. There was a positive correlation between values of serum 1,25 dihydroxyvitamin D and intestinal calcium absorption in both groups. However, in patients with primary hyperparathyroidism, intestinal calcium absorption was more increased than that in normal volunteers when compared to their serum values of 1,25 dihydroxyvitamin D. This suggests that another factor than 1,25 dihydroxyvitamin D plays an important role in the intestinal calcium absorption in patients with primary hyperparathyroidism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Deluca HF (1976) Vitamin D endocrinology. Ann Int Med 85:367–374
Garabedian M, Tanaka Y, Holick MF et al. (1974) Response or intestinal calcium transport and bone calcium mobilization to 1,25 dihydroxyvitamin D3 in thyroparathyroi-dectomized rats. Endocrinology 94:1022–1027
Haussler MR, Bursac KM, Bove H et al. (1975) Increased circulating 1,25 dihydroxyvitamin D3 in patients with primary hyperparathyroidism. Clin Res 23:322A
Kaplan RA, Haussler MR, Deftos LJ et al. (1977) The role of 1,25 dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria. J Clin Invest 59:756–760
Morita R, Fukunaga M, Dokoh S, et al. (1978) Differential diagnosis of hypercalcemia by measurement of parathyroid hormone, calcitonin and 25-hydroxyvitamin D. J Nucl Med 19:1225–1230
Dokoh S, Pike JW, Chandler JS, et al. (1981) An improved radioreceptor assay for 1,25 dihydroxyvitamin D in human plasma. Anal Biochem 116:211–221
Morita R, Yamamoto I, Fukunaga M, et al. (1979) Changes in sex hormones and calcium-regulating hormones with reference to bone mass associated with aging. Endocrinol Japan Supl 1:15–22
Lutwak L (1969) Tracer studies of intestinal calcium absorption in man. Am J Clin Nutr 22:771–785
Avioli LV, Birge SJ, Lee SW (1968) Effects of prednisone on vitamin D metabolism in man. J Clin Endocrin Metab 28:1341–1346
Shohl AT (1936) Rickets in rat XV. The effect of low calcium-high phosphorus diets at various levels and ratios upon the production of rickets and tetany. J Nutr 11:275–285
Breslau NA, Mcquire JL, Zererkh JE, et al. (1982) The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism. J Clin Endocrinol Metab 55:369–373
Dent RI, James JH, Wang CA et al. (1972) Hyperparathyroidism: gastric acid secretion and gastrin. Ann Surg 176:360–369
Bussabarger RA, Freeman S, Ivy AC (1938) The experimental production of severe homogeneous osteoporosis by gastrectomy in puppies. Am J Physiol 121:137–145
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hino, M., Yamamoto, I., Shigeno, C. et al. Evidence that factors other than 1,25 dihydroxyvitamin D may play a role in augmenting intestinal calcium absorption in patients with primary hyperparathyroidism. Calcif Tissue Int 38, 193–196 (1986). https://doi.org/10.1007/BF02556710
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02556710