Abstract
Questions on this topic that concern the clinician are addressed: whether it is inherited and, if so, whether Mendelian; what the segregation ratios will be; whether it is heterogeneous; how its high frequency can be accounted for; and what preventive measures are availabel. In several cases the question has to be reworded in order to make it sufficiently precise for it to be used in practice without misleading the patient. Framed in this fashion applicable answers are relatively easily available although many genetic puzzles remain. To date, no antenatal diagnosis is available.
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References
Murphy EA, Krush AJ. Familial polyposis coli. In: Steinberg AG, Bearn AG, Motulsky AG, Childs B, eds. Progress in medical genetics, Philadelphia: WB Saunders, 1980;4:59–101.
Veale AM. Intestinal polyposis. Eugenics laboratory memoirs series. London, Cambridge University Press, 1965.
Murphy EA, Krush AJ, Dietz M, Rohde CA. Hereditary polyposis coli. III. Genetic and evolutionary fitness. Am J Hum Genet 1980; 32:700–13.
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The preparation of this paper was supported by grants GM24736 and AGO1334 from the National Institutes of Health, and from the Baker Foundation.
Editor's Note: The following two papers continue a series, begun in the June, 1983 issue, concerning heritable neoplastic diseases affecting the colorectum.
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Murphy, E.A. Genetic aspects of multiple polyposis coli. Dis Colon Rectum 26, 470–474 (1983). https://doi.org/10.1007/BF02556530
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DOI: https://doi.org/10.1007/BF02556530