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Comparison of growth retarding effects induced by two different glucocorticoids in prepubertal sick children: An interim long-term analysis

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Summary

The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) age 3–12 yrs, after a median period of 14 mo.s is reported. Children with connective tissues (CTD) and glomerular disorders (KD) were randomly allocated to DFZ or PDN. Anthropometric measurements and maturity ratings were performed. Mean daily doses of PDN (or DFZ equivalent), from 0.57 to 0.64 mg/kg (DFZ 0.92 to 0.94 mg/kg) to induce control and from 0.19 to 0.93 mg/kg (DFZ 0.34 to 0.36 mg/kg) to maintain disease under control were given in CTD and KD, respectively. The increase in bone age delay over time was significantly>for PDN(-4.0 mo/yr) than DFZ (-1.8 mo/yr) in the overall group. The increases in statural age delay and loss over time were significantly> for PDN (-5.9 and-5.9 mo/yr) than DFZ (-2.4 and-2.4 mo/yr), only in children with “taller” midparents. Although doses of DFZ 1.1–1.8 times those of PDN were given, growth retardation in PDN-treated children was nevertheless 2.3–2.5 times that in DFZ-ones.

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References

  1. Loeb JN (1976). Corticosteroids and growth. New Engl J Med: 295, 547–552

    Article  PubMed  CAS  Google Scholar 

  2. Henderson IC, Loeb JN (1974). Hormone-induced changes in liver DNA synthesis: effects of glucocorticoids and growth hormone on liver growth and DNA polymerase activity. Endocrinology: 94, 1637–1643

    Article  PubMed  CAS  Google Scholar 

  3. Morris HG, Jorgensen JR, Elrich H, Goldsmith RE (1968). Metabolic effects of human growth hormone in corticosteroid-treated children., J Clin Invest: 47, 436–451

    PubMed  CAS  Google Scholar 

  4. Daughaday WH, Herington AC, Phillips LS (1975). The regulation of growth by endocrines. Annu Rev Physiol: 37, 211–244

    Article  PubMed  CAS  Google Scholar 

  5. Nathanshon G, Pasqualucci GR, Radaelli P, Schiatti P, Selva D, Winters G (1969). Steroids possessing nitrogen atoms. V(1) Some pharmacological and chemicophysical aspects of a new class of active corticoids: (17 alfa, 16 alfa-D)-oxazolino-steroids. Steroids: 13, 365–381

    Article  Google Scholar 

  6. Hahn TJ Halstead LR, Strates B, Imbimbo B, Baran DT (1980). Comparison of subacute effects of oxazacort and prednisone on mineral metabolism in man. Calcif Tissue Int: 31, 109–115

    Article  PubMed  CAS  Google Scholar 

  7. Gennari C, Imbimbo B, Montagnani M, Bernini M, Nardi P, Avioli LV (1984). Effects of prednisone and deflazacort on mineral metabolism and parathyroid hormone activity in humans Calcif Tissue Int: 36, 245–252

    Article  PubMed  CAS  Google Scholar 

  8. Gennari C, Bernini M, Nardi P, Fusi L, Francini G, Nami R, Montagnani M, Imbimbo B, Avioli LV (1983). Glucocorticoids: radiocalcium and radiophosphate absorption in man. In: Dixon ASJ, Russell RGG, Stamp TCB eds. Osteoporosis, a multidisciplinary problem. Royal Society of Medicine. Int congress and symposium series, No 55. Academic Press, London, p. 75–80.

    Google Scholar 

  9. Imbimbo B, Tuzi T, Porzio F, Schiavetti L (1984). Clinical equivalence of a new glucocorticoid, deflazacort and prednisone in rheumatoid arthritis and S.L.E. patients. Adv Exp Med Biol: 171, 241–256

    PubMed  CAS  Google Scholar 

  10. Imbimbo B, Milani S (1986). Equivalenza clinica e tollerabilità relativa dei glucocorticoidi: stima dei rapporti di potenza e di danno. In: Avioli LV, Gennari G, Imbimbo B eds. Glucocorticoid effects and their biological consequences: advances in glucocorticoid therapy. Excerpta Medica, Amsteram, p. 13–22

    Google Scholar 

  11. Lo Cascio V, Bonucci E, Imbimbo B, Ballanti P, Tartarotti D, Galvanin, G, Fuccella L and Adami S (1984). Bone loss after glucocorticoids therapy. Calcif Tissue Int: 36, 435–438

    Article  PubMed  Google Scholar 

  12. Gennari C, Imbimbo B (1985). Effects of prednisone and deflazacort on vertebral bone mass. Calcif Tissue Int: 37, 592–593

    PubMed  CAS  Google Scholar 

  13. Nagant de Deuxchaisnes C, Devogelaer JP, Huaux JP, Dufour JP, Esselinckx W, Stasse P (1986). The effect of small equivalent doses of deflazacort and prednisone on the bone mineral content in male patients with rheumatoid arthritis. J Bone Mineral Res, suppl 1: abstract No. 172

  14. Balsan S, Steru D, Bourdeau A, Grimberg R, Lenoir C (1987). Effects of long-term maintenance therapy with a new glucocorticoid, deflazacort, on mineral metabolism and statural growth. Calcif Tissue Int: 40, 303–309

    Article  PubMed  CAS  Google Scholar 

  15. Cameron N (1984). The measurement of human growth. Croom-Helm, London

    Google Scholar 

  16. Tanner JM, Whitehouse RH (1976). Clinical longitudinal standards for height, weight, height velocity and weight velocity and the stages of puberty. Arch Dis Child: 51, 170–179

    PubMed  CAS  Google Scholar 

  17. Tanner JM, Whitehouse RH (1975). Revised standards for triceps and subscapular skinfolds in British children. Arch Dis Child: 50, 142-?

    PubMed  CAS  Google Scholar 

  18. Aicardi C, Di Battista E, Naselli A, Vignolo M, De Scrilli A (1986). Affidabilità dei più comuni metodi di previsione della statura adulta su un campione di adolescenti Italiani. Acta Med Auxol: 18, 55–65

    Google Scholar 

  19. Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJR, Goldstein H (1983). Assessment of skeletal maturity and prediction of adult height (TW2 method), 2nd ed. Academic Press, London

    Google Scholar 

  20. Roche AF, Wainer H, Thissen D (1975). Predicting adult stature for individuals. Monogr Pediatr: 3, 1–114

    CAS  Google Scholar 

  21. Vignolo M, Milani S, Di Battista E, Naselli A, Mostert M, Aicardi G (1990). Modified Greulich-Pyle, Tanner-Whitehouse and Roche-Wainer-Thissen (Knee) methods for skeletal age assessment in a group of Italian children and adolescents. Eur J Pediatr: 149, 314

    Article  PubMed  CAS  Google Scholar 

  22. Tanner JM (1986). Use and abuse of growth standards. In: F. Falkner and JM Tanner eds, vol 3. Plenum Press, New York, p. 104

    Google Scholar 

  23. Searle SR (1971). Linear models. Wiley, London

  24. SAS Institute Inc (1985). SAS introductory guide for personal computers. 6th ed. Cary

  25. Loftus JK, Allen R, Hesp R, Green JR, Reeve J, Ansell BM, Woo P (1989). A comparative trial of deflazacort and prednisone in Juvenile Chronic Arthritis. Am Soc Bone Mineral Res, Int Conference on Calcium and Related Hormones. Montreal, 14 Sept

  26. Loftus JK, Allen R, Hesp R, Green JR, Reeve J, Ansell BM, Woo P (1990). Treatment of Juvenile Chronic Arthritis (JCA): Deflazacort permits proportionate growth in lumbar spine bone mineral content in a randomized trial with prednisone. Clin Sci, Suppl 22: 4, 13

    Google Scholar 

  27. Blodgett FM, Burgin L, Lezzoni D, Gribetz D, Talbot NB (1956). Effect of prolonged cortisone treatment on the statural growth, skeletal maturation and metabolic status of children. New Engl J Med: 254, 636–641

    Article  PubMed  CAS  Google Scholar 

  28. Kerrebijn KF, Kroon JPM (1968). Effect on height of corticosteroid therapy in asthmatic children. Arch Dis Child: 43, 556

    PubMed  CAS  Google Scholar 

  29. Mosier HD Jr, Jansons RA, Hill RR (1976). Cartilage sulfation cortisone-induced growth arrest. Endocrinology: 99, 580

    PubMed  CAS  Google Scholar 

  30. Gutman AB, Yu TF (1950). A concept of the role of enzymes in endochondral calcification In: Metabolic interrelations. Transactions second conference Josiah Macy Foundation, New York, p. 167

  31. Meyer WL, Kunin AS (1969). Decreased glycolytic enzyme activity in epyphyseal cartilage of cortisome-treated rats. Arch Biochem Biophys: 129, 431–437

    Article  PubMed  CAS  Google Scholar 

  32. Russell JE, Gennari C, Imbimbo B, Avioli LV (1985). Effects of deflazacort and L-6485 metabolite on epyphyseal cartilage carbohydrate metabolism: comparison with prednisone. Horm Metabol Res: 17, 402–405

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto di Puericultura e Medicine Neonatale “L.Gaslini”, Università di Genova, Genova, Italy

    G. Aicardi

  2. Istituto di Statistica Medica e Biometria, Università di Milano, Milano, Italy

    S. Milani

  3. Medical Dept. Gruppo Lepetit S.p.A., Grandate, Como, Italy

    B. Imbimbo

  4. Divisione di Nefrologia e Dialisi, Istituto G. Gaslini, Genova, Italy

    M. Vignolo, E. Di Battista & R. Gusmano

  5. Clinica di Malattie Infettive, Università di Genova, Genova, Itay

    A. Terragna

  6. Clinica Pediatrica I “Gaslini”, Università di Genova, Genova, Italy

    G. Cordone & F. Cottafava

  7. Divisione di Nefrologia e Dialisi, Ospedale Infantile ‘Regina Margherita”, Torino, Italy

    R. Coppo & M. G. Porcellini

  8. Divisione di Pediatria, Ospedale di Giaveno, Torino, Italy

    O. Sernia

  9. Divisione di Pediatria, Ospedale Infantile “Regina Margherita”, Torino, Italy

    M. L. Sardella

  10. Centro di Auxopatologia, Università di Torino, Torino, Italy

    M. Barottø & L. Benso

Authors
  1. G. Aicardi
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  2. S. Milani
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  3. B. Imbimbo
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  4. M. Vignolo
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  5. E. Di Battista
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  6. R. Gusmano
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  7. A. Terragna
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  8. G. Cordone
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  9. F. Cottafava
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  10. R. Coppo
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  11. O. Sernia
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  12. M. G. Porcellini
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  13. M. L. Sardella
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  14. M. Barottø
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  15. L. Benso
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Aicardi, G., Milani, S., Imbimbo, B. et al. Comparison of growth retarding effects induced by two different glucocorticoids in prepubertal sick children: An interim long-term analysis. Calcif Tissue Int 48, 283–287 (1991). https://doi.org/10.1007/BF02556381

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  • DOI: https://doi.org/10.1007/BF02556381

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