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Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone

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Summary

Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10−12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.

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Authors and Affiliations

  1. Department of Oral Biology, School of Dental Medicine, State University of NY at Buffalo, 14214, Buffalo, New York, USA

    Dimitris N. Tatakis, Gerald Schneeberger & Rosemary Dziak

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  1. Dimitris N. Tatakis
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  2. Gerald Schneeberger
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  3. Rosemary Dziak
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Tatakis, D.N., Schneeberger, G. & Dziak, R. Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone. Calcif Tissue Int 42, 358–362 (1988). https://doi.org/10.1007/BF02556353

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  • DOI: https://doi.org/10.1007/BF02556353

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