Skip to main content

Advertisement

SpringerLink
Log in

Pulsatile secretion of parathyroid hormone and its action on a type I and type II PTH receptor: A hypothesis for understanding osteoporosis

  • Editorial
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Parfitt AM (1976) The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Metabolism 25:809–955

    Article  PubMed  CAS  Google Scholar 

  2. Crowley WF Jr, Filicori M, Spratt, D, Santoro N (1985) The physiology of gonadotropin releasing hormone secretion in men and women. Rec Prog Horm Res 41:473–531

    PubMed  CAS  Google Scholar 

  3. Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto R, Togol AD, Kaiser DL, Thorner MO (1987) Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 64:51–58

    PubMed  CAS  Google Scholar 

  4. Brabant G, Brabant A, Ranft U, Owan K, Kohrle J, Hesch RD, von zur Muhlen A (1987) Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration. J Clin Endocrinol Metab 65:83–88

    PubMed  CAS  Google Scholar 

  5. van Cauter E, Refetoff S (1985) Evidence for two subtypes of Cushing's diseases based on the analysis of episodic cortisol secretion. N Engl J Med 312:1343–1349

    Article  PubMed  Google Scholar 

  6. Zor U (1983) Role of cytoskeletal organization in the regulation of adenylate cyclase-cyclic AMP by hormones. Endocrinol Rev 4:1–21

    CAS  Google Scholar 

  7. Montminy MR, Belezikian LM (1987) Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328:175–178

    Article  PubMed  CAS  Google Scholar 

  8. Berridge MJ, Irvine RF (1984) Inositol triphosphate a novel second messenger in cellular signal transduction. Nature 312:315–321

    Article  PubMed  CAS  Google Scholar 

  9. Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca++ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5 triphosphate. Nature 306:67–69

    Article  PubMed  CAS  Google Scholar 

  10. Woods NM, Cuthbertson KSR, Cobbold PH (1986) Repetitive transient rises in cytoplasmatic free calcium in hormone-stimulated hepatocytes. Nature 319:600–602

    Article  PubMed  CAS  Google Scholar 

  11. Cambier JC, Newell MK, Justement LB, McGuire JC, Leach KL, Chen ZZ (1987) Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature 327:629–632

    Article  PubMed  CAS  Google Scholar 

  12. Ratan RR, Shelanski ML (1986) Calcium and the regulation of mitotic events. TIBS 11:456–459

    CAS  Google Scholar 

  13. Spratt DI, Finkelstein JS, Butler JP, Badger TM, Crowley WF (1987) Effects of increasing the frequency of low doses of gonadotropin-releasing hormone (GNRH) on gonadotropin secretion in GNRH-deficient men. ICEM 64(No 6): 1179–1186

    CAS  Google Scholar 

  14. Glass L (1987) Coupled oscillators in health and disease. In: Rensing L, an der Heiden U, Machey MC (eds) Temporal disorder in human oscillatory systems. Springer Verlag, Berlin Heidelberg New York London Paris Tokyo, pp 8–14

    Google Scholar 

  15. Goldbeter A (1987) Periodic signaling and receptor desensitization: from cAMP oscillations in Dicotstyleum cells to pulsatile patterns of hormone secretion. In: Rensing L, an der Heiden V, Machey MC (eds) Temporal disorder in human oscillatory systems. Springer Verlag, pp 15–23

  16. Harms H, Kapteina U, Kulpmann T, Hesch RD (1987) The pulse amplitude and frequency modulation of PTH secretion in man. Int Symp on Osteoporosis, Aalborg (Abstract 232)

  17. Hesch RD, Herrmann G, Perris AD, Atkinson MJ (1986) Type II PTH receptor-operated calcium channel and its importance for PTH peptide elevations in coronary artery disease. Am J Nephrol 6(suppl 1):155–161

    Article  PubMed  Google Scholar 

  18. Hruska KA, Goligorsky M, Scoble J, Tsutsumi MT, Westbook S, Moskowitz D (1986) Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures. Am J Physiol 251:F188-F198

    PubMed  CAS  Google Scholar 

  19. Hruska KA, Moskowitz D, Esbrit P, Civitelli R, Huskey M (1987) Stimulation of inositol triphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone. J Clin Invest 79:230–239

    Article  PubMed  CAS  Google Scholar 

  20. Reid IR, Civitelli R, Avioli LV, Hruska KA (1987) Evidence for new second messengers of PTH in osteoblast-like cells. Int Symp on Osteoporosis, Aalborg (Abstract 76)

  21. Yee JA, Sutton JK, Shew RL, Olansky L (1986) Parathyroid hormone stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells: involvement of cyclic AMP and calcium. J Cell Physiol 128:246–250

    Article  PubMed  CAS  Google Scholar 

  22. Wakelam MJO, Murphy GJ, Hruby VJ, Honsly MD (1986) Activation of two signals in hepatocytes by glucagon. Nature 323:68–71

    Article  PubMed  CAS  Google Scholar 

  23. Mallat A, Pavoine C, Dufour M, Cotersztajn S, Bataille D, Pecker F (1987) A glucagon fragment is responsible for the inhibition of the liver Ca++ pump by glucagon. Nature 325:620–622

    Article  PubMed  CAS  Google Scholar 

  24. Burbach JPH, Kovacs GL, de Wied D, van Nipsen JW, Greven HM (1983) A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. Science 221:1310–1312

    Article  PubMed  CAS  Google Scholar 

  25. van Leeuven FW (1987) New 3H arginine vasopressin antagonist: a specific and sensitive means to show vasopressin binding in the brain. Biotechnology Update 2:1–2

    Google Scholar 

  26. Knights EG, Baylin SB, Foster GV (1973) Control of polypeptide hormones by enzymatic degradation. Lancet 11:719–723

    Article  Google Scholar 

  27. Chambers TJ (1987) The regulation of osteoclastic function. Int Symp on Osteoporosis, Aalborg (Abstract 290)

  28. Yee JA (1985) Stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells by parathyrois hormone. Calcif Tissue Int 37:530–538

    PubMed  CAS  Google Scholar 

  29. Lowik CWGM, van Leeuwen JPTM, van der Meer JM, van Zeeland JK, Scheven BAA, Herrmann-Erke MPM (1985) A two-receptor model for the interaction of parathyroid hormone on osteoblasts: a role for intracellular-free calcium and cAMP. Cell Calcium 6:311–326

    Article  PubMed  CAS  Google Scholar 

  30. Atkinson MJ, Schettler T, Bodenstein H, Hesch RD (1984) Osteoporosis: a bone turnover defect resulting from an elevated parathyroid hormone concentration within the bone marrow cavity? Klin Wschr 62:129–132

    Article  PubMed  CAS  Google Scholar 

  31. Santoro N, Wirman ME, Filicori M, Walsteicher J, Crowley WF (1986) Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage. J Clin Endocrinol Metab 62:109–116

    PubMed  CAS  Google Scholar 

  32. Avgerinos PC, Schurmeyer TH, Gold PW, Tomai TP, Loriaux DL, Sherius RJ, Cuther GB, Chronsos GP (1986) Pulsatile administration of human corticotropin-releasing hormone in patients with secondary adrenal insufficiency: restoration of the normal cortisol secretory pattern. J Clin Endocrinol Metab 62:816–821

    Article  PubMed  CAS  Google Scholar 

  33. Hesch RD, Harms H (1986) Episodic secretion of parathyroid hormone and osteoporosis. In: Wagner TOF, Filicori M (eds) Episodic hormone secretion: from basic science to clinical application. TM-Verlag 1987 ISBM-3-921936-14-4

  34. Slovic DM, Rosenthal DI, Doppelt SH, Potts JT, Daly MA, Campbell JA, New RM (1986) Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25 dihydroxy-vitamin D. J Bone Min Res 1:377–381

    Article  Google Scholar 

  35. Rittinghaus EF, Busch U, Prokop M, Delling G, Hesch RD (1987) Dramatic increase of bone-mass and turnover in osteoporosis by combined (1–38)hPTH and calcitonin therapy. Int Symp on Osteoporosis, Aalborg (Abstract 365)

Download references

Author information

Authors and Affiliations

  1. Abteilung Klinische Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, 3 Hannover 61, Germany

    R. D. Hesch, G. Brabant, E. F. Rittinghaus, M. J. Atkinson & H. Harms

Authors
  1. R. D. Hesch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Brabant
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. F. Rittinghaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. J. Atkinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Harms
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hesch, R.D., Brabant, G., Rittinghaus, E.F. et al. Pulsatile secretion of parathyroid hormone and its action on a type I and type II PTH receptor: A hypothesis for understanding osteoporosis. Calcif Tissue Int 42, 341–344 (1988). https://doi.org/10.1007/BF02556350

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02556350

Search

Navigation