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Production and characterization of new monoclonal antibodies to human osteoclasts

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Summary

Two monoclonal antibodies raised against human osteoclastoma were found to show antiosteoclastic activity on frozen sections of tumor. Immunoreactivity was localized on the membrane surface. These antibodies exhibited no activity against tissue macrophages and human visceral tissue except kidney, where they stained tubules but not glomeruli. In addition, no activity was observed against rabbit or rat osteoclasts, suggesting that they might react with unique epitopes on human osteoclasts.

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Authors and Affiliations

  1. Department of Histopathology, St. George's Hospital Medical School, Tooting, SW17 ORE U.K., London, U.K.

    P. N. Nelson & T. J. Chambers

  2. Department of Morbid Anatomy, Institute of Orthopaedics, Royal National Orthopaedic Hospital, Stanmore, Middlesex, U.K.

    J. A. S. Pringle

Authors
  1. P. N. Nelson
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  2. J. A. S. Pringle
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  3. T. J. Chambers
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Nelson, P.N., Pringle, J.A.S. & Chambers, T.J. Production and characterization of new monoclonal antibodies to human osteoclasts. Calcif Tissue Int 49, 317–320 (1991). https://doi.org/10.1007/BF02556253

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  • DOI: https://doi.org/10.1007/BF02556253

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