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1-Hydroxyethylidene-1,1-bisphosphonate decreases the postovariectomy enhanced interleukin 1 secretion from peritoneal macrophages in adult rats

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Summary

Bisphosphonates are potent inhibitors of bone resorption. In previous studies, we have shown that ovariectomy accelerated bone resorption and 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) inhibits ovariectomy-accelerated bone resorption in female Wistar adult rats. As interleukin 1 (IL-1) stimulates bone resorptionin vitro andin vivo, we have investigated the effects of ovariectomy and HEBP administeredin vivo on IL-1 secretion from peritoneal macrophages in adult rats. Ovariectomy or sham surgery were performed in female Wistar rats at 40 weeks of age. Overiectomized and sham-operated rats were administered with HEBP (10 mg) or saline, 10 times in total, from 43 to 46 weeks of age. Paraffin oil-induced peritoneal macrophages at 46 weeks of age were cultured for 24 hours. Lipopolysaccharide (LPS)-stimulated peritoneal macrophages from ovariectomized rats secreted more IL-1 than sham-operated rats. HEBP decreased LPS-stimulated IL-1 secretion from peritoneal macrophages in ovariectomized rats, but not in sham-operated rats.In vivo administration of HEBP decreased IL-1 secretion only in postovariectomy hyperresorptive states. These results suggest that alterations in LPS-stimulated IL-1 secretion from oil-induced peritoneal macrophages may be responsible, at least in part, for the postovariectomy acceleration in bone resorption and its inhibition by HEBP.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Shiga University of Medical Science, Otsu, 520−21, Shiga, Japan

    Takashi Matsuda & Shinsuke Hukuda

  2. Department of Orthopedic Surgery, Komatsu Hospital, Neyagawa, 572, Osaka, Japan

    Kiyoaki Matsui

  3. Clinical Research and Development Office, Sumitomo Pharmaceuticals Co., Ltd., 541, Osaka, Osaka, Japan

    Yoshikazu Shimakoshi

  4. Department of Endodontics and Periodontics, Faculty of Dentistry, Kyusyu University, 812, Fukuoka, Fukuoka, Japan

    Yoshitomi Aida

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  1. Takashi Matsuda
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  2. Kiyoaki Matsui
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  3. Yoshikazu Shimakoshi
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  4. Yoshitomi Aida
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  5. Shinsuke Hukuda
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Matsuda, T., Matsui, K., Shimakoshi, Y. et al. 1-Hydroxyethylidene-1,1-bisphosphonate decreases the postovariectomy enhanced interleukin 1 secretion from peritoneal macrophages in adult rats. Calcif Tissue Int 49, 403–406 (1991). https://doi.org/10.1007/BF02555851

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  • DOI: https://doi.org/10.1007/BF02555851

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