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Effects of tumor necrosis factor alpha on parathyroid hormone-induced increases in osteoblastic cell cyclic AMP

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Summary

Tumor necrosis factor α (10−10–10−8M) had no effects on cyclic AMP production by the osteoblastic osteosarcomal cells, Saos-2 and G292, or normal rat calvarial cells. The cytokine did, however, inhibit the parathyroid hormone (PTH)-induced effect on cyclic AMP in the Saos-2 and normal rat osteoblastic cells. This inhibitory effect did not occur on prostaglandin E2-induced cyclic AMP increases in the osteoblastic cells. Interleukin-1 (10 U/ml −100 U/ml) did not produce any effect on basal levels or PTH-induced cyclic AMP increases in these cells.

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Authors and Affiliations

  1. Department of Endodontics, State University of New York-Buffalo, Buffalo, New York, USA

    Stewart Shapiro

  2. Department of Oral Biology, SUNY-Buffalo, School of Dental Medicine, 14214, Buffalo, NY, USA

    Dimitris N. Tatakis &  Rosemary Dziak

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  1. Stewart Shapiro
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  2. Dimitris N. Tatakis
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  3. Rosemary Dziak
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Shapiro, S., Tatakis, D.N. & Dziak, R. Effects of tumor necrosis factor alpha on parathyroid hormone-induced increases in osteoblastic cell cyclic AMP. Calcif Tissue Int 46, 60–62 (1990). https://doi.org/10.1007/BF02555826

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  • DOI: https://doi.org/10.1007/BF02555826

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