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Involvement of low-calcium diet in the reduced bone mineral content of idiopathic renal stone formers

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Summary

The possibility that low-calcium intake in renal stone formers could lead to reduced bone mineral content was investigated in 123 male patients with idiopathic urolithiasis. Radius bone mineral content, (BMC) was measured by single photon absorptiometry. Two groups of patients were analyzed: group 1 (n=63) maintained on a free diet; group 2 (n=60) maintained on a low-calcium diet (350 mg/day ±20 SEM) for 3.9 years ±0.6 SEM. The two groups of patients were investigated after a standard reduction of calcium intake for at least 1 week. The urinary excretion of calcium and of hydroxyproline, and the serum alkaline phosphatase activity were higher in both groups than in normal subjects submitted to the same low-calcium diet. Both groups of stone formers showed lowered radius BMC values at 3 cm (distal) and 8 cm (proximal) above the styloid process, but distal BMC was significantly lower in group 2 than in group 1. The results suggest that low-calcium intake could worsen the already decreased BMC of idiopathic renal stone formers.

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References

  1. Fuss M, Gillet C, Simon J, Vandewalle J-C, Schoutens A, Bergmann P (1983) Bone mineral content in idiopathic stone disease and in primary hyperparathyroidism. Eur Urol 9:32–34

    PubMed  CAS  Google Scholar 

  2. Alhava EM, Juuti M, Karjalainen P (1976) Bone mineral density in patients with urolithiasis. Scand J Urol Nephrol 10:154–156

    Article  PubMed  CAS  Google Scholar 

  3. Lawoyin S, Sismilich S, Browne R, Pak CYC (1979) Bone mineral, content in patients with calcium urolithiasis. Metabolism 28:1250–1254

    Article  PubMed  CAS  Google Scholar 

  4. Pak CYC, Kaplan R, Bone H, Towsend J, waters O (1975) A simple test for the diagnosis of absorptive, resorptive and renal hypercalciuria. N Engl J Med 292:497–500

    Article  PubMed  CAS  Google Scholar 

  5. Barkin J, Wilson DR Manuel MA, Bailey A, Murray T, Harrison J (1985) Bone mineral content in idiopathic calcium nephrolithiasis. Mineral Electrolyte Metab 11:19–24

    CAS  Google Scholar 

  6. Fuss M, Pepersack T, Corvilain J, Vandewalle JC, Van Geertruyden J, Simon J, Kinnaert P (1988) Infrequency of primary hyperparathyroidism in renal stone formers. Br J Urol 62:4–6

    Article  PubMed  CAS  Google Scholar 

  7. Fuss M, Verbeelen D, Geurts J, Simon J, Bergans A, De Backer M, Six R, Corvilain J (1978) The use of a test for the differential diagnosis of hypercalciuria. Eur Urol 4:324–329

    CAS  Google Scholar 

  8. Tovey KC, Oldham KG, Whelan SAM (1974) A simple direct assay for cyclic AMP in plasma and other, biological samples using an improved competitive protein-binding technique. Clin Chim Acta 56:221–234

    Article  PubMed  CAS  Google Scholar 

  9. Delfosse L, Orloff S, Rao VH, Shosberg E, Verbruggen L (1975) Automated analysis of hydroxyproline in urine. Ind J Biochem Biophys 12:280–282

    CAS  Google Scholar 

  10. Cameron JR, Sorensen J (1963) Measurement of bone mineral in vivo: an imporved method. Science 142:230–232

    Article  PubMed  CAS  Google Scholar 

  11. Scheffe H (1959) The analysis of variance. John Wiley, New York, p 477

    Google Scholar 

  12. Rao DS, Wilson RJ, Kleerekoper M, Parfitt M (1988) Lack of biochemical progression or continuation of accelerated bone loss in mild, asymptomatic primary hyperparathyroidism: evidence for a biphasic course. J Clin Endocrinol Metab 67:1294–1298

    PubMed  CAS  Google Scholar 

  13. Malm OJ (1958) Calcium requirement and adaption in adult men. Scand J Clin Lab Invest 10 (suppl 36):1–289

    PubMed  CAS  Google Scholar 

  14. Steggerda FR, Mitchell HH (1951) Calcium balance of adult human subjects on a high and low fat (butter) diet. J Nutr 45:201–211

    PubMed  CAS  Google Scholar 

  15. Conference report. Consensus development conference: prophylaxis and treatment of osteoprosis (1987), Br Med J 295:914–915

  16. Nordin BEC (1960) Osteomalacia, osteoporosis and calcium defeciency. Clin Orthop 17:235–257

    Google Scholar 

  17. Dallas I, Nordin BEC (1962) Dietary calcium and radiological osteoporosis. Am J Clin Nutr 11:263–269

    PubMed  CAS  Google Scholar 

  18. Matkovic V, Kostial K, Simonovic I, Buzina R, Brodarec A, Nordin, BEC (1979) Bone status and fracture rates in two regions of Yugoslavia. Am J Clin Nutr 32:540–549

    PubMed  CAS  Google Scholar 

  19. Holbrook TL, Barrett-Connor E, Wingard DL (1988) Dietary calcium and risk of hip fracture: 14-year prospective population study. Lancet 2:1046–1049

    Article  PubMed  CAS  Google Scholar 

  20. Jowsey J, Raisz L (1968) Experiemental osteoporosis and calcium deficiency. Endocrinology 82:382–396

    Google Scholar 

  21. Parfitt AM, Higgins BA, Nassim JR, Collins JA, Collins JA, Hilb A (1964) Metabolic studies in patients with hypercalciuria. Clin Sci 27:463–482

    PubMed  CAS  Google Scholar 

  22. Edwards NA, Hodgkinson A (1965) Metabolic studies in patients with idiopathic hypercalciuria. Clin Sci 29:143–157

    PubMed  CAS  Google Scholar 

  23. Liberman UA, Sperling O, Atsmon A, Frank M, Modan M de Vries A (1968) Metabolic and calcium kinetic studies in idiopathic hypercalciuria. J Clin Invest 47:2580–2590

    PubMed  CAS  Google Scholar 

  24. Coe FL, Favus MJ, Crockett T, Strauss AL, Parks JH, Porat A, Gantt CL, Sherwood LM (1982) Effects of low-calcium diet on urine calcium excretion, parathyroid function and serum, 1,25(OH)2D3 levels in patients with idiopathic hypercalciuria and in normal subjects. Am J Med 72:25–32

    Article  PubMed  CAS  Google Scholar 

  25. Coe FL, Canterbury, JM, Firpo JJ, Reiss E (1973) Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. J Clin Invest 52:134–142

    Article  PubMed  CAS  Google Scholar 

  26. Muldowney FP, Freaney R, Ryan JG (1980) The pathogenesis of idiopathic hypercalciuria: evidence of renal tubulous calcium leak. Q J Med 49:87–94

    PubMed  CAS  Google Scholar 

  27. Burckhardt P, Jaeger P (1981) Secondary hyperparathyroidism in idiopathic renal hypercalciuria: fact or theory? J Clin Endocrinol Metab 53:550–555

    PubMed  CAS  Google Scholar 

  28. Walker VR, Sutton RAL (1984) Urinary cyclic 3′5′-monophosphate in idiopathic calcium stone formers. Response to an oral calcium-load. Clin Sci 66:193–199

    PubMed  CAS  Google Scholar 

  29. Pak CYC (1976) Idiopathic renal lithiasis: new developments in evaluation and treatment. In: Fleisch H, Robertson WG, Smith LH, Vahlensieck W (eds) Urolithiasis research. Plenum Press, New York, London, p 213.

    Google Scholar 

  30. Shen FH, Baylink DJ, Nielsen RL, Sherrard DJ, Ivey JL, Haussler MR (1977) Increased serum 1,25-dihydroxy vitamin D in idiopathic hypercalciuria. J Lab Clin Med 6:955–962

    Google Scholar 

  31. Broadus AE, Insogna KL, Lang R, Ellison AF, Dreyer BE (1984) Evidence for disordered control of 1,25-dihydroxytitamin D production in absorptive hypercalciuria. N Engl J Med 311:73–80

    Article  PubMed  CAS  Google Scholar 

  32. Maierhofer MF, Gray RW, Cheung HS, Lemann J (1984) Dietary clacium and serum 1,25(OH)2-vitamin D concentrations as determinants of calcium balance in healthy men. Kidney Int 26:752–759

    PubMed  CAS  Google Scholar 

  33. Bordier P, Ryckewart A, Gueris J, Rasmussen H (1977) On the pathogenesis of so-called idiopathic hypercalciuria. Am J Med 63:398–409

    Article  PubMed  CAS  Google Scholar 

  34. Sutton AL, Walker VR (1986) Bone resorption and hypercalciuria in calcium stone formers. Metabolism 35:485–488

    Article  PubMed  CAS  Google Scholar 

  35. Malluche HH, Tschoepe W, Ritz E, Meyer-Sabellek W, Massry SG (1980) Abnormal bone histology in idiopathic hypercalciuria. J Clin Endocrinol Metab 50:654–658

    Article  PubMed  CAS  Google Scholar 

  36. Fillipponi P, Manarelli C, Pacifi R, Grossi E, Moretti I, Tini S, Carloni C, Blass A, Morucci P, Hruska KA, Avioli LV (1988) Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int 43:61–66

    Google Scholar 

  37. Ray WA, Downey W, Griffin MR, Melton LJ III (1989) Long-term use of thiazide diuretics and risk of hip fracture. Lancet 1:687–690

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Hôpital Universitaire Brugmann, Place A. Van Gehuchten 4, 1020, Brussels, Belgium

    Jean-Claude Vandewalle

  2. Department of Nuclear Medicine, Hôpital Universitaire Brugmann, Place A. Van Gehuchten 4, 1020, Brussels, Belgium

    Pierre Bergmann

  3. Department of Urology, Hôpital Erasme, Université Libre de Bruxelles, Place A. Van Gehuchten 4, 1020, Brussels, Belgium

    Jacques Simon

  4. Department of Internal Medicine, Endocrinology Unit, Hôpital Universitaire Brugmann, Place A. Van Gehuchten 4, 1020, Brussels, Belgium

    Michel Fuss, Thierry Pepersack, Jean Van Geel & Jacques Corvilain

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  2. Thierry Pepersack
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  3. Jean Van Geel
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  5. Jean-Claude Vandewalle
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  6. Pierre Bergmann
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  7. Jacques Simon
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Fuss, M., Pepersack, T., Van Geel, J. et al. Involvement of low-calcium diet in the reduced bone mineral content of idiopathic renal stone formers. Calcif Tissue Int 46, 9–13 (1990). https://doi.org/10.1007/BF02555818

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  • DOI: https://doi.org/10.1007/BF02555818

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