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A gamma-detecting probe for radioimmune detection of CEA-producing tumors

Successful experimental use and clinical case report

  • Published:
Diseases of the Colon & Rectum

Abstract

The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.

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Author information

Authors and Affiliations

  1. Section of Surgical Oncology, the Ohio State University, Columbus, Ohio

    Delmar R. Aitken M.D. (American Cancer Society Fellow in Clinical Oncology), David Houchens Ph.D. & Edward W. Martin Jr. M.D.

  2. Department Of Pathology, the Ohio State University, Columbus, Ohio

    George H. Hinkle M.S., R.Ph. & John Olsen M.D.

  3. Department Of Electrical Engineering, the Ohio State University, Columbus, Ohio

    Marlin O. Thurston Ph.D.

  4. Battelle Memorial Institute, Columbus, Ohio

    Darrow E. Haagensen Jr. M.D., PhD.

  5. Harvard Medical School, Boston, Massachusetts

    Daniel T. Martin M.D.

  6. Department of Surgery, the Ohio State University, 410 West 10th Avenue, 43210-1228, Columbus, Ohio

    Steve E. Tuttle M.D.

Authors
  1. Delmar R. Aitken M.D.
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  2. George H. Hinkle M.S., R.Ph.
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  3. Marlin O. Thurston Ph.D.
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  4. Steve E. Tuttle M.D.
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  5. Daniel T. Martin M.D.
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  6. John Olsen M.D.
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  7. Darrow E. Haagensen Jr. M.D., PhD.
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  8. David Houchens Ph.D.
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  9. Edward W. Martin Jr. M.D.
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Additional information

Read at the meeting of The American Society of Colon and Rectal Surgeons, Boston, Massachusetts, June 5–9, 1983.

Supported by PHs Grant No. CA 18016 awarded by the National Cancer Institute, DHHS.

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Cite this article

Aitken, D.R., Hinkle, G.H., Thurston, M.O. et al. A gamma-detecting probe for radioimmune detection of CEA-producing tumors. Dis Colon Rectum 27, 279–282 (1984). https://doi.org/10.1007/BF02555625

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  • DOI: https://doi.org/10.1007/BF02555625

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