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Anaplastic solitary extramedullary plasmacytoma of the cecum

Report of a case confirmed by immunoperoxidase staining

  • Published:
Diseases of the Colon & Rectum

Abstract

Solitary extramedullary plasma cell tumors, although uncommon, have been reported with increasing frequency over the last few years. Approximately 5 to 10 percent of the tumors arise in the gastrointestinal tract. This report demonstrates that a solitary anaplastic cecal extramedullary plasmacytoma can mimic a polypoid carcinoma, both grossly and, to an extent, microscopically. Immunoperoxidase stains for cytoplasmic immunoglobulin proved useful in establishing the correct diagnosis.

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References

  1. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine 1976;55:217–38.

    Article  PubMed  CAS  Google Scholar 

  2. Henry K, Farrer-Brown G. Primary lymphomas of the gastrointestinal tract. I. Plasma cell tumors. Histopathology 1977;1:53–76.

    PubMed  CAS  Google Scholar 

  3. Grody WM, Weiss LM, Warnke RA, et al. Gastrointestinal lymphomas: immunohistochemical studies of the cell of origin. Am J Surg Pathol 1985;9:328–37.

    Article  PubMed  CAS  Google Scholar 

  4. Wiltshaw E. Chemotherapy in the management of extramedullary plasmacytoma. Cancer Chemother Pharmacol 1978;1:167–75.

    Article  PubMed  CAS  Google Scholar 

  5. Callihan TR, Holbert JM Jr, Berard CW. Neoplasms of terminal B-cell differentiation: the morphologic basis of tumoral diversity. In: Sommers SC, Rosen PP, eds. Malignant lymphomas: a pathology annual monograph. Norwalk CT: Appleton-Century-Crofts, 1983:169–268.

    Google Scholar 

  6. Warnke RA, Rouse RV. Limitations encountered in the application of tissue section immunodiagnosis to the study of lymphomas and related disorders. Hum Pathol 1984;16:326–31.

    Google Scholar 

  7. Graham RC Jr, Berner GM. The bone marrow in multiple myeloma: correlation of plasma cell ultrastructure and clinical state. Medicine 1975;54:225–43.

    Article  PubMed  Google Scholar 

  8. Strand WR, Banks PM, Kyle RA. Anaplastic plasma cell myeloma and immunoblastic lymphoma: clinical, pathologic, and immunologic comparison. Am J Med 1984;76:861–7.

    Article  PubMed  CAS  Google Scholar 

  9. Saraga P, Hurlimann J, Ozello L. Lymphomas and pseudolymphomas of the alimentary tract: an immunohistochemical study with clinicopathologic correlations. Hum Pathol 1981;12:713–723.

    Article  PubMed  CAS  Google Scholar 

  10. Gatter KC, Alcock C, Heryet A, et al. The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies. Am J Clin Pathol 1984;82:33–43.

    PubMed  CAS  Google Scholar 

  11. Kurtin PJ, Pinkus GS. Leukocyte common antigen—a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol 1985;16:353–65.

    PubMed  CAS  Google Scholar 

  12. Pinkus GS, Kurtin PJ. Epithelial membrane antigen—a diagnostic discriminant in surgical pathology: immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasm using paraffin sections and monoclonal antibodies. Hum Pathol 1985;16:929–40.

    Article  PubMed  CAS  Google Scholar 

  13. Gleason TH, Hammar SP. Plasmacytoma of the colon: case report with lambda light chain, demonstrated by immunoperoxidase studies. Cancer 1982;50:130–3.

    Article  PubMed  CAS  Google Scholar 

  14. Foucar K, Raber M, Foucar E, et al. Anaplastic myeloma with massive extramedullary involvement: report of two cases. Cancer 1983;51:166–74.

    Article  PubMed  CAS  Google Scholar 

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Sperling, R.I., Fromowitz, F.B. & Castellano, T.J. Anaplastic solitary extramedullary plasmacytoma of the cecum. Dis Colon Rectum 30, 894–898 (1987). https://doi.org/10.1007/BF02555432

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  • DOI: https://doi.org/10.1007/BF02555432

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