Abstract
Melanosis coli was diagnosed histologically in colon biopsies of 45 patients with prolonged administration of anthraquinone laxatives. Colonoscopies performed for increased constipation, abdominal pains, or distention disclosed discoloration of the mucosa in only 14 patients. Radiographic studies revealed motility disorders of the colon. In several cases, a circular stenosis occurred at the junction of the colon and the sigmoid, simulating a tumor. Electron microscopy showed abnormalities of the absorptive epithelial cells. The lamina propria contained pigment-laden macrophages, plasma cells, and several nerve fibers in different stages of degeneration. The most striking changes of autonomic nerve elements occurred in patients with the most serious motility disorders.
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References
Sleisenger MH, Fordtran JS. Gastrointestinal disease: pathophysiology, diagnosis, management. Philadelphia: WB Saunders, 1978:1860–2.
Bruckstein AH. Laxatives and cathartics: uses and abuses. NY State J Med 1978;78:1078–82.
Göbel D. Melanosis coli. Med Klin 1978;73:519–23.
Steer HW, Colin-Jones DG. Melanosis coli: studies of the toxic effects of irritant purgatives. J Pathol 1975;115:199–206.
Cummings JH, Laxative abuse. Gut 1974;15:758–66.
Speare GS. Melanosis coli: experimental observations on its production and elimination in twenty-three cases. Am J Surg 1951;82:631–7.
Ghadially FN, Parry EW. An electron-microscope and histochemical study of melanosis coli. J Pathol 1966;92:313–7.
Badiali D, Marcheggiano A, Pallone F, et al. Melanosis of the rectum in patients with chronic constipation. Dis Colon Rectum 1985;28:241–5.
Smith B. Pathology of cathartic colon. Proc R Soc Med 1972;65:288.
Smith B. Pathologic changes in the colon produced by anthraquinone purgatives. Dis Colon Rectum 1973;16:455–8.
Riemann JF, Schenk J, Ehler R, et al. Ultrastructural changes of colonic mucosa in patients with chronic laxative misuse Acta Hepato-Gastroenterol 1978;25:213–8.
Riemann JF, Schmidt H, Zimmermann W. The fine structure of colonic submucosal nerves in patients with chronic laxative abuse. Scand J Gastroenterol 1980;15:761–8.
Riemann JF, Schmidt H. Ultrastructural changes in the gut autonomic nervous system following laxative abuse and in other conditions. Scand J Gastroenterol [suppl] 1982;71:111–24.
Gershon MD, Erde SM. The nervous system of the gut. Gastroenterology 1981;80:1571–94.
Krishnamurthy S, Schuffler MD, Rohmann CA, Pope CE III. Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus. Gastroenterology 1985;88:26–34.
Schmidt H, Riemann JF, Schmid A, Sailer D. Ultrastructure of diabetic autonomic polyneuropathy of the gastrointestinal tract. Klin Wochenschr 1984;62:399–405.
Dvorak AM, Silen W. Differentiation between Crohn's disease and other inflammatory conditions by electron microscopy. Ann Surg 1985;201:53–63.
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Balázs, M. Melanosis coli. Dis Colon Rectum 29, 839–844 (1986). https://doi.org/10.1007/BF02555359
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DOI: https://doi.org/10.1007/BF02555359