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Osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of OI

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Summary

Samples of human osteogenesis imperfecta (OI) bone were analyzed for osteonectin content by SDS gel electrophoresis and immunodetection on Western blots. The OI bone osteonectin content varied from normal to severely depressed. Previously, we showed that two clinically identical but genetically unrelated bovine methods of OI were differentiated biochemically by their bone osteonectin content: one OI mode had normal bone osteonectin while the other was severely depressed in this parameter. The data in this pilot study suggest that further investigation of bone osteonectin content may prove useful in the clinical assessment of human OI cases.

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Authors and Affiliations

  1. Bone Research Branch, National Institute of Dental Research, National Institutes of Health, 20892, Bethesda, Maryland

    L. W. Fisher, P. Gehron Robey, K. M. Conn & J. D. Termine

  2. Clinical Investigations and Patients Care Branch, National Institute of Dental Research, National Institutes of Health, 20892, Bethesda, Maryland

    M. A. Drum

Authors
  1. L. W. Fisher
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  2. M. A. Drum
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  3. P. Gehron Robey
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  4. K. M. Conn
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  5. J. D. Termine
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Fisher, L.W., Drum, M.A., Robey, P.G. et al. Osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of OI. Calcif Tissue Int 40, 260–264 (1987). https://doi.org/10.1007/BF02555258

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  • DOI: https://doi.org/10.1007/BF02555258

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