Summary
Mandibular bone resorption in normal and osteoporotic rats was measured using standard scintillation techniques for tritiated tetracycline (H3-TC). Thirty-four Sprague-Dawley rats were labeled with H3-TC at 4–9 weeks of age. Ten animals were then sacrificed for baseline radioactivity levels, while 12 experimental animals were given a high protein, low calcium diet, and 12 control animals were given a normal calcium diet. Osteoporotic and normal diets were instituted for 90 days. The results show a significant reduction in the quantity of bone in the experimental group (P<.05) as compared to the control group. In addition, serum samples collected were found to contain significantly elevated (P<.01) alkaline phosphatase level in the experimental group when compared to the control group.
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Sones, A.D., Wolinsky, L.E. & Kratochvil, F.J. Osteoporosis and mandibular bone resorption in the sprague dawley rat. Calcif Tissue Int 39, 267–270 (1986). https://doi.org/10.1007/BF02555217
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DOI: https://doi.org/10.1007/BF02555217