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Effect of 1α-hydroxycholecalciferol on psoriasis vulgaris: A pilot study


We carried out a clinical trial of 1α-hydroxycholecalciferol [1α(OH)D3] at a dose of 1.0 μg a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical corticosteroids was continued on 6 of the 7 patients. Four of 7 patients showed complete remission and marked improvement and 2 additional patients showed minimal improvement of their skin lesions during and after the treatment with 1α(OH)D3. No adverse reactions were noted during the treatment period. The mechanism of the phenomenon we observed has yet to be elucidated. Controlled trials of large numbers of patients with psoriasis vulgaris treated with 1α(OH)D3 are under way.

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Correspondence to T. Onishi M.D..

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Takamoto, S., Onishi, T., Morimoto, S. et al. Effect of 1α-hydroxycholecalciferol on psoriasis vulgaris: A pilot study. Calcif Tissue Int 39, 360–364 (1986).

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Key words

  • 1α-hydroxycholecalciferol
  • 1α,25-dihydroxycholecalciferol
  • Vitamin D
  • Calcium
  • Psoriasis vulgaris
  • Skin