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Peak trabecular vertebral density: A comparison of adolescent and adult females


To determine when spinal bone density reaches its peak, the trabecular vertebral density was assessed, via quantitative computed tomography, among females from two age groups: (1) adolescents (aged 14–19 years; n=24); and (2) young adults (aged 25–35 years; n=24). The adolescent girls had a higher mean trabecular vertebral density (P<0.01), suggesting that spinal density reaches its peak around the time of cessation of longitudinal growth and epiphyseal closure.

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  1. 1.

    Johnston CC, Hui SL, Wiske P (1981) Bone mass at maturity and subsequent rates of loss as determinants of osteoporosis. In: De Luca HF, Frost HM, Jee WSS (eds) Osteoporosis: Recent advances in pathogenesis and treatment. University Park Press, Baltimore, p 285

    Google Scholar 

  2. 2.

    Gilsanz V, Gibbens DT, Roe TF, Carlson M, Senac MO, Boechat MI, Huang HK, Schulz EE, Libanati CR, Cann CE (1988) Vertebral bone density in children: Effect of puberty. Radiology 166:847–850

    PubMed  CAS  Google Scholar 

  3. 3.

    Cann CE (1981) Low dose CT scanning for quantitative spinal mineral analysis. Radiology 140:813–815

    PubMed  CAS  Google Scholar 

  4. 4.

    Cann, CE, Genant HK (1980) Precise measurement of vertebral mineral content using CT. J Comput Assist Tomogr 4:493–500

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Genant HK, Cann CE, Pozzi-Mucelli RS, Kanter AS (1983) Vertebral mineral determination by quantitative CT: Clinical feasibility and normative data. J Comput Assist Tomogr 7:554

    Article  Google Scholar 

  6. 6.

    Villanueva AR, Sedlin E, Frost HM (1983) Variations in osteoblastic activity with age. Anat Rec 146:209

    Article  Google Scholar 

  7. 7.

    Weaver JK, Chalmers J (1966) Cancellous bone; its strength and changes with aging and an evaluation of some methods for measuring its mineral content. I. Age changes in cancellous bone. J Bone Joint Surg 48A:289

    Google Scholar 

  8. 8.

    Merz WA, Schenk RK (1970) A quantitative histological study on bone formation in human cancellous bone. Acta Anat 76:1

    PubMed  CAS  Article  Google Scholar 

  9. 9.

    Arnold JS (1973) Amount of quality of trabecular bone in osteoporotic and vertebral fractures. Clin Endocrinol Metab 2:221

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Marcus R, Kosen J, Pfefferbaum A, Horning A (1983) Age-related loss of trabecular bone in premenopausal women: A biopsy study. Calcif Tiss Int 35:406

    Article  CAS  Google Scholar 

  11. 11.

    Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Gonzalez O, Carlson ME Boechat MI (Revision requested) Effect of sex steroids on peak bone density of growing rabbits. Am J Physiol.

  12. 12.

    Cann CE, Ettinger B, Genant HK (1985) Normal subjects versus osteoporotics: No evidence using dual energy computed tomography for disproportionate increase in vertebral marrow fat. J Comput Assist Tomogr 9:617

    Article  Google Scholar 

  13. 13.

    Burgess AE, Colborne B, Zoffman E (1987) Vertebral trabecular bone: Comparison of single and dual-energy CT measurements with chemical analysis. J Comp Assist Tomogr 11:506

    CAS  Article  Google Scholar 

  14. 14.

    Cummings SR (1987) Epidemiology of osteoporotic fractures: Selected topics. In: Roche AF, Gussler JD, Redfern DE (eds) Report of the Seventh Ross Conference on medical research. Ross Laboratories, Columbus, p 3

    Google Scholar 

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Correspondence to Vicente Gilsanz.

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Gilsanz, V., Gibbens, D.T., Carlson, M. et al. Peak trabecular vertebral density: A comparison of adolescent and adult females. Calcif Tissue Int 43, 260–262 (1988).

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  • Bone Density
  • Quantitative Compute Tomography
  • Trabecular Bone Density
  • Vertebral Trabecular Bone
  • Epiphyseal Closure