Summary
Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 μM. Iron (III) ions (Fe), at concentrations up to 10 μM, have no effect on the dissolution process of HAP. The Fe-chelating agent desferrioxamine also forms strong complexes with Al but not with Cr. Desferrioxamine prevents the adsorption of Al to HAP and removes pre-adsorbed Al from the HAP surface, although not instantaneously, but has no significant effect on the adsorption of Cr to HAP. Desferrioxamine is also found to be capable of removing Al preadsorbed to bone powder.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boyce BF, Elder HY, Fell GS, Nicholson WAP, Smith GD, Dempster DW, Gray CC, Boyle IT (1981) Quantitation and localisation of aluminium in human cancellous bone in renal osteodystrophy. Scanning Electron Microscopy III:329–337
Maloney NA, Ott SM, Alfrey AC, Miller NL, Coburn JW, Sherrard DJ (1982) Histological quantitation of aluminum in iliac bone from patients with renal failure. J Lab Clin Med 99:206–216
Delling von G, Schäfer HJ, Krumme H, Schulz W (1983) Renale osteopathie und aluminium-pathomorphologie. Nieren- und Hochdruckkrankheiten 12:207–213
Verbueken AH, Van de Vyer FL, Van Griecken RE, Paulus GJ, Visser WJ, D'Haese P, De Broe ME (1984) Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia. Clin Chem 30:763–768
Malluche HH, Smith AJ, Abreo K, Faugere M-C (1984) The use of deferoxamine in the management of aluminum accumulation in bone in patients with renal failure. New Engl J Med 311:140–144
Brown DJ, Dawborn JK, Ham KN, Xipell JM (1982) Treatment of dialysis osteomalacia with desferrioxamine. Lancet 2:343–345
Mudde AH, Roodvoets AP (1982) Desferrioxamine and osteomalacia. Lancet 2:608
Weatherell JA, Robinson C (1982) Action of trace elements in the mineralisation of hard tissues. Proc Finn Dent Soc 78:81–92
Christoffersen MR, Christoffersen J (1985) The effect of aluminum on the rate of dissolution of calcium hydroxyapatite—a contribution to the understanding of aluminum-induced bone diseases. Calcif Tissue Int 37:673–676
Christoffersen J, Christoffersen MR, Kjaergaard N (1978) The kinetics of dissolution of calcium hydroxyapatite in water at constant pH. J Cryst Growth 43:501–511
Burgess J (1978) Metal ions in solution. Horwood, Chichester, p 317
Nielson AE (1984) Electrolyte crystal growth mechanisms. J Crystal Growth 67:289–310
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Christoffersen, M.R., Thyregod, H.C. & Christoffersen, J. Effects of aluminum(III), chromium(III), and iron(III) on the rate of dissolution of calcium hydroxyapatite crystals in the absence and presence of the chelating agent desferrioxamine. Calcif Tissue Int 41, 27–30 (1987). https://doi.org/10.1007/BF02555127
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02555127