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Role of oestrogen in the development of osteoporosis

Calcified Tissue International volume 49, pages S55–S59 (1991)Cite this article

Summary

The evidence now strongly supports a central role for oestrogen in the maintenance of the normal female skeleton. Loss of endogenous oestrogen leads to a period of accelerated bone loss which can be prevented with appropriate oestrogen replacement. The route of administration is not important provided adequate dosages are prescribed. Oestrogens may exert their actions by a direct steroid receptor mechanism or via local and/or systemic factors such as cytokines, prostaglandins or calcitonin. As the requirement for osteoporosis prevention grows, it is essential that the extent of the involvement oestrogen has in skeletal homeostasis is fully recognized.

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  1. Wynn Institute for Metabolic Research, 21 Wellington Road, NW8 9SQ, London, England

    Timothy C. Hillard & John C. Stevenson

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  1. Timothy C. Hillard
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  2. John C. Stevenson
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Hillard, T.C., Stevenson, J.C. Role of oestrogen in the development of osteoporosis. Calcif Tissue Int 49 (Suppl 1), S55–S59 (1991). https://doi.org/10.1007/BF02555090

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