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Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone

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Summary

Urinary excretion of calcium (Ca) was measured in 9 patients with pseudohypoparathyroidism (PHP) type I—3 with Albright's hereditary osteodystrophy (AHO): AHO(+) and 6 without AHO: AHO(−)—and in 13 with idiopathic hypoparathyroidism (IHP), treated with active vitamin D3 (1,25(OH)2D3 or 1αOHD3) to maintain serum Ca levels at 8.4–9.5 mg/dl. Fasting urinary excretion of Ca in PHP was significantly lower than that in IHP. Moreover, fasting urinary excretion of Ca in PHP AHO(+) was lower than that in PHP AHO(−). This difference was also seen in the urine after oral loading of Ca. Urinary excretion, of sodium (Na) was not different between PHP AHP(+) and PHP AHO(−). Serum levels of immunoreactive PTH in PHP AHO(+) were higher than those in PHP AHO(−). The difference in urinary excretion of Ca between PHP AHO(+) and PHP AHO(−) may come from the difference in the circulating levels of PTH.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Tohoku University School of Medicine, Seiryocho 1-1, Sendai, Japan

    Kazutoshi Mizunashi, Hyo Euy Sohn, Ryo Miura, Shigeru Yumita & Kaoru Yoshinaga

  2. Department of Internal Medicine, Sendai City Hospital, Sendai, Japan

    Yohtaro Furukawa

Authors
  1. Kazutoshi Mizunashi
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  2. Yohtaro Furukawa
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  3. Hyo Euy Sohn
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  4. Ryo Miura
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  5. Shigeru Yumita
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  6. Kaoru Yoshinaga
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Mizunashi, K., Furukawa, Y., Sohn, H.E. et al. Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone. Calcif Tissue Int 46, 227–232 (1990). https://doi.org/10.1007/BF02555000

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  • DOI: https://doi.org/10.1007/BF02555000

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