Summary
Urinary excretion of calcium (Ca) was measured in 9 patients with pseudohypoparathyroidism (PHP) type I—3 with Albright's hereditary osteodystrophy (AHO): AHO(+) and 6 without AHO: AHO(−)—and in 13 with idiopathic hypoparathyroidism (IHP), treated with active vitamin D3 (1,25(OH)2D3 or 1αOHD3) to maintain serum Ca levels at 8.4–9.5 mg/dl. Fasting urinary excretion of Ca in PHP was significantly lower than that in IHP. Moreover, fasting urinary excretion of Ca in PHP AHO(+) was lower than that in PHP AHO(−). This difference was also seen in the urine after oral loading of Ca. Urinary excretion, of sodium (Na) was not different between PHP AHP(+) and PHP AHO(−). Serum levels of immunoreactive PTH in PHP AHO(+) were higher than those in PHP AHO(−). The difference in urinary excretion of Ca between PHP AHO(+) and PHP AHO(−) may come from the difference in the circulating levels of PTH.
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Albright F, Burnett CH, Smith PH, Parson W (1942) Pseudohypoparathyroidism—an example of “Seabright-Bantam syndrome”. Endocrinology 30:922–932
Elrick H, Albright F, Bartter FC (1950) Further studies on pseudohypoparathyroidism: report of four new cases. Acta Endocrinol (Copenh) 5:199–225
Chase LR, Melson GL, Aurbach GD (1969) Pseudohypoparathyroidism: defective excretion of 3′,5′-AMP in response to parathyroid hormone. J Clin Invest 48:1832–1844
Drezner MK, Neelon FA, Haussler M, McPherson HT, Lebovitz HE (1976) 1,25-Dihydroxycholecalciferol, deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. J Clin Endocrinol Metab 42:621–628
Sinha TK, Deluca HF, Bell NH (1977) Evidence for a defect in the formation of 1,25-dihydroxyvitamin D in pseudohypoparathyroidism. Metabolism 26:731–738
Lambert PW, Hollis BW, Bell NH, Epstein S (1980) Demonstration of a lack of change in serum 1,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism. J Clin Invest 66:782–791
Aksnes L, Aarsko D (1980) Effect of parathyroid hormone on 1,25-dihyroxyvitamin D formation in type I pseudohypoparathyroidism. J Clin Endocrinol Metab 51:1223–1226
Drezner MK, Neelon FA (1985) Pseudohypoparathyroidism. In: Stanbury JB, Wyngaarden JB, Frederickson, DS, Goldstein JL, Brown MS (eds) Metabolic basis of inherited disease, 5th ed. McGraw-Hill, New York, pp 1508–1528
Drezner MK, Haussler MR (1979) Normocalcemic pseudohypoparathyroidism: association with normal vitamin D3 metabolism. Am J Med 66:503–508
Breslau NA, Notman DD, Canterbury JM, Moses AM (1980) Studies on the attainment of normocalcemia in patients with pseudohypoparathyroidism. Am J Med 68:856–860
Mason RS, Lisner D, Posen S (1980) Parathyroid hormone effect on 1,25-dihydroxyvitamin D in hypoparathyroidism. Ann Intern Med 92:260
Drezner MK, Neelon FA, Lebovitz HE (1973) Pseudohypoparathyroidism type II: a possible defect in the reception of the cyclic AMP signal. N Engl J Med 289:1056–1060
Rodrquez HJ, Villareal H Jr, Klahr S, Slatopolsky E (1974) Pseudohypoparathyroidism, type II: restoration of normal responsiveness to parathyroid hormone by calcium administration. J Clin Endocrinol Metab 39:693–701
Yamamoto M, Takuwa Y, Masuko S, Ogata E (1988) Effects of endogenous and exogenous parathyroid hormone on tubular reabsorption of calcium in pseudohypoparathyroidism. J Clin Endocrinol Metab 6:618–625
Saito T, Akita Y, Fuita H, Furukawa Y, Tsuchiya Y, Yasuda T, Yamamoto M, Kitagawa T, Nakagawa Y, Takehiro A, Fujita T, Komada S, Kuzuya T (1986) Stimulatory guanine nucleotide binding protein activity in the erythrocyte membrane of patients with pseudohypoparathroidism type I and related disorders. Acta Endocrinol 111:507–515
Sohn HE, Furukawa Y, Yumita S, Miura R, Unakami H, Yoshinaga K (1984) Effect of synthetic 1–34 fragment of human parathyroid hormone on plasma adenosine 3′,5′-monophosphate (cAMP) concentrations and the diagnostic criteria based on the plasma cAMP response in Ellsworth-Howard test. Endocrinol JPN 31:33–40
Broadus AE, Dominguez M, Bartter FC (1978) Pathophysiological studies in idiopathic hypercalciuria: use of an oral calcium tolerance test to characterize distinctive hypercalciuric subgroups. J Clin Endocrinol Metab 47:751–760
Mizunashi K, Furukawa Y, Miura R, Yumita S, Sohn HE, Yoshinaga K (1988) Effects of active vitamin D3 and parathyroid hormone on serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism. J Clin Invest 82:861–865
Fiske CH, Subbarow Y, (1925) The calorimetric determination of phosphorus. J Biol Chem 66:375–400
Brod J, Sirota JH (1948) The renal clearance of endogenous creatinine in man. J Clin Invest 27:645–654
Marx SJ, Liberman UA, Eil C (1983) Calciferols: actions and deficiencies in action. Vitam Horm 40:235–308
Russell J, Silver J, Sherwood LM (1984) The effects of calcium and vitamin D metabolites on cytoplasmic mRNA coding for pre-proparathyroid hormone in isolated parathyroid cells. Trans Assoc Am Physicians 97:296–303
Silver J, Russell J, Sherwood LM (1985) Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 82:4270–4273
Moses AM, Breslau N, Coulson R (1976) Renal responses to PTH in patients with hormone-resistant(Pseudo) hypoparathyroidism. Am J Med 61:184–189
Loveridge N, Fisher JA, Devogelaer J-P, Nagant de Deuxchaisnes C (1986) Suppression of parathyroid hormone inhibitory activity of plasma in pseudohypoparathyroidism type I by calcium. Clin Endocrinol (Oxf) 24:549–554
Mitchell J, Goltzman D (1985) Examination of circulating parathyroid hormone in pseudohypoparathyroidism. J Clin Endocrinol Metab 61:328–334
Loveridge N, Fisher JA, Nagant de Deuxchaisnes C (1982) Inhibition of cytochemical bioactivity of parathyroid hormone by plasma in pseudohypoparathyroidism type I. J Clin Endocrinol Metab 54:1274–1275
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Mizunashi, K., Furukawa, Y., Sohn, H.E. et al. Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone. Calcif Tissue Int 46, 227–232 (1990). https://doi.org/10.1007/BF02555000
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DOI: https://doi.org/10.1007/BF02555000