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Effects of prednisone and deflazacort on vertebral bone mass

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Summary

The effects of a 12-month therapeutic course of two different glucocorticoids, prednisone and deflazacort (an oxazoline derivative of predinisolone), on vertebral and femoral bone was analyzed by dual photon absorptiometry. The data, which reveal a significantly less bone loss with deflazacort (9.7% in 12 months) than with prednisone (21.4% in 12 months), further document the advantage of deflazacort as a glucocorticoid medication in subjects with osteopenic syndromes.

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Authors and Affiliations

  1. Institute of Medical Semeiotics, University of Siena, Italy

    C. Gennarl

  2. Medical Department, Gruppo Lepetit SpA, Milan, Italy

    B. Imbimbo

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  1. C. Gennarl
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  2. B. Imbimbo
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Gennarl, C., Imbimbo, B. Effects of prednisone and deflazacort on vertebral bone mass. Calcif Tissue Int 37, 592–593 (1985). https://doi.org/10.1007/BF02554912

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  • DOI: https://doi.org/10.1007/BF02554912

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