Abstract
Anticholinesterases are the mainstay in the treatment of myasthenia gravis. They are also used in the reversal of neuromuscular blocking agents used during general anesthesia. Their use in gastrointestinal surgery, especially involving anastomosis of the distal ileum or colon, has been implicated in anastomotic disruptions. This paper discusses the controversy in the use of reversal agents (anticholinesterases) in colon surgery and specifically in patients with myasthenia gravis.
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References
Harrington-Kiff JG. Timing of atropine and neostigmine in the reversal of muscle relaxants. Br Med J 1969;1:418–20.
Goligher JC. Surgery of the anus, rectum, and colon. 4th ed. London: Bailliere-Tindall, 1980.
Bell CM, Lewis CB. Effect of neostigmine on integrity of ileorectal anastomosis. Br Med J 1968;3:587–8.
Wilkins JL, Hardcastle JD, Mann CV. Effects of neostigmine and atropine on motor activity of ileum, colon, and rectum of anesthetized subjects. Br Med J 1970;1:793–4.
Chaudhary NA, Truelove SC. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. Gastroenterology 1961;40:1–17.
Deeler DJ, Wangel AG. Intestinal motility in man. Gastroenterology 1965;48:45–57.
Adler HF, Atkinson AJ, Ivy AC. Effect of morphine and dilaudid on the ileum and of morphine, dilaudid and atropine on the colon of men. Arch Intern Med 1942;69:974–85.
Eckenoff JE, Cannard TH. Influence of anesthetic agents and adjuvants upon intestinal tone. Anesthesiology 1960;21:96–7.
Doteval G, Kock NG. The effect of glucagon on intestinal motility in man. Gastroenterology 1963;45:364–7.
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Herz, B.L. Colonic anastomotic disruption in myasthenia gravis. Dis Colon Rectum 30, 809–811 (1987). https://doi.org/10.1007/BF02554633
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DOI: https://doi.org/10.1007/BF02554633