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Peutz-Jeghers polyposis associated with carcinoma of the digestive organs

Report of three cases and review of the literature

  • Published:
Diseases of the Colon & Rectum

Abstract

Three cases of Peutz-Jeghers polyposis with carcinoma of the digestive organs are studied. Although mucocutaneous pigmentation was not present in two of the three patients, the features of intestinal polyposis are consistent with those of Peutz-Jeghers syndrome. One patient had a carcinoma of the pancreas and the other two had carcinomas with colonic Peutz-Jeghers polyps. Previous reports on carcinomas associated with Peutz-Jeghers syndrome are reviewed. An unusual location in the gastrointestinal tract, together with occurrence at an early age, characterize the carcinoma in Peutz-Jeghers syndrome. In Japanese patients, the large bowel is the site of the greatest number of carcinomas. On the other hand, Western patients showed a relatively even distribution. A possible surveillance protocol for early detection of gastrointestinal carcinoma in patients with Peutz-Jeghers syndrome is discussed.

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Authors and Affiliations

  1. First Department of Surgery, University of Tokyo, Tokyo, Japan

    Fumio Konishi M.D., Norma E. Wyse B.A., Tetsuichiro Muto M.D., Toshio Sawada M.D., Yasuhiko Morioka M.D., Haruhiko Sugimura M.D. & Kazuyoshi Yamaguchi M.D.

  2. Department of Pathology, University of Tokyo, Tokyo, Japan

    Fumio Konishi M.D., Norma E. Wyse B.A., Tetsuichiro Muto M.D., Toshio Sawada M.D., Yasuhiko Morioka M.D., Haruhiko Sugimura M.D. & Kazuyoshi Yamaguchi M.D.

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  1. Fumio Konishi M.D.
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  2. Norma E. Wyse B.A.
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Konishi, F., Wyse, N.E., Muto, T. et al. Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Dis Colon Rectum 30, 790–799 (1987). https://doi.org/10.1007/BF02554629

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  • DOI: https://doi.org/10.1007/BF02554629

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