Abstract
The authors have developed a hand-held gamma-detecting probe (GDP) for intraoperative use that improves the sensitivity of external radioimmunodetection. Radiolabeled monoclonal antibody (MAb) B72.3 was injected in six patients with primary colorectal cancer and 31 patients with recurrent colorectal cancer an average of 16 days preoperatively. The GDP localized the MAb B72.3 in 83 percent of sites. The technique, known as a radioimmunoguided surgery (RIGSTM) system did not alter the surgical procedure in patients with primary colorectal cancer but did alter the approach in 26 percent (8/31) of patients with recurrent colorectal cancer. Two patients avoided unnecessary liver resections and two underwent extraabdominal approaches to document their disease. The RIGS system may influence the short-term morbidity and mortality of surgery for colorectal cancer. Larger series and longer follow-up are needed to determine whether the RIGS system confers a survival advantage to the patient with colorectal cancer.
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References
Silverberg E, Lubera J. Cancer statistics 1987. CA 1987;37:2–19.
American Cancer Society: Colon and rectum cancer. 1986 Cancer Facts and Figures: 9.
Minton JP, Hoehn JL, Gerber DM, et al. Results of a 400 patient carcinoembryonic antigen second-look colorectal cancer study. Cancer 1985;55:1284–90.
Lokich JJ. Systemic infusional chemotherapy for liver metastasis: an improved schedule for 5-fluorouracil. Recent Results Cancer Res 1986;100:131–9.
Begent RH, Keep PA, Searle F, et al. Radioimmunolocalization and selection for surgery in recurrent colorectal cancer. Br J Surg 1986;73:64–7.
Moldofsky PJ, Sears HF, Mulhern CB, et al. Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal-antibody imaging. N Engl J Med 1984;311:106–7.
DeLand FH, Kim EE, Primus FJ, Dine ME, Goldenberg DM. In vivo radioimmunodetection of occult recurrent colonic carcinoma. AJR 1982;138:145–8.
Mach JP, Carrel S, Forni M, Ritschard J, Donath A, Alberto P, Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation. N Engl J Med 1986;303:5–10.
Rockoff SD, Goodenough DJ, McIntire KR. Theoretical limitations in the immunodiagnostic imaging of cancer with computed tomography and nuclear scanning. Cancer Res 1980;40: 3054–8.
Aitken DR, Hinkle GH, Thurston MO, et al. A gamma-detecting probe for radioimmune detection of CEA-producing tumors: successful experimental use and clinical case report. Dis Colon Rectum 1984;27:279–82.
Martin DT, Hinkle GH, Tuttle S, et al. Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. Am J Surg 1985;150:672–5
O'Dwyer PJ, Mojzisik CM, Hinkle GH, et al. Intraoperative probe-directed immunodetection using a monoclonal antibody. Arch Surg 1986;121:1391–4.
Colcher D, Horan HP, Nuti M, Schlom J. A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc Natl Acad Sci USA 1981;78:3199–3203.
Stramignoni D, Bowen R, Atkinson BF, Schlom J. Differential reactivity of monoclonal antibodies with human colon adenocarcinomas and adenomas. Int J Cancer 1983;31:543–52.
Porter D, Tuttle S, Bucci D, Jewell S, Colcher D, Schlom J. Distribution of B72.3 antigen in primary and metastatic colorectal carcinoma (abstr). Lab Invest 1987;56:61A.
Thor A, Ohuchi N, Szpak CA, Johnston WW, Schlom J. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res 1986;46: 3118–24.
Goldenberg DM, DeLand F, Kim E, et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med 1978;298:1384–8.
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Read at the meeting of the American Society of Colon and Rectal Surgeons, Washington, D.C., April 5 to 10, 1987.
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Sickle-Santanello, B.J., O'Dwyer, P.J., Mojzisik, C. et al. Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis Colon Rectum 30, 761–764 (1987). https://doi.org/10.1007/BF02554623
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DOI: https://doi.org/10.1007/BF02554623