Abstract
A 24-year-old woman with a two-year history of inflammatory bowel disease, with no anal or perineal involvement, underwent a proctocolectomy and ileostomy. Pathologic evaluation of the specimen revealed Crohn's colitis and unsuspected perianal Bowen's disease. The patient is free of Crohn's and Bowen's disease 6.5 years later. The association of perianal Bowen's disease with Crohn's colitis is discussed.
Similar content being viewed by others
References
Preston DM, Fowler EF, Lennard-Jones JE, Hawley PR. Carcinoma of the anus in Crohn's disease. Br J Surg 1983;70:346–7.
Slater G, Greenstein A, Aufses AH. Anal carcinoma in patients with Crohn's disease. Ann Surg 1984;199:348–50.
Daly JJ, Madrazo A. Anal Crohn's disease with carcinoma in situ. Dig Dis Sci 1980;25:464–6.
Bowen JT. Precancerous dermatose: a study of 2 cases of chronic atypical epithelial proliferation. J Cutan Dis 1912;30:241–55.
Vickers PM, Jackman RJ, McDonald JR. Anal carcinoma in situ: report of three cases. South Surg 1939;8:503–7.
Beck DE, Fazio VW. Perianal Bowen's disease. Dis Colon Rectum 1988;31:419–22.
Wood WA, Culling CF. Perianal Paget's disease: histochemical differentiation utilizing the borhydride-KOH-PAS reaction. Arch Pathol 1975;99:442–5.
Grodsky L. Intraepidermal cancer of the anus: evolution to invasive growth. Calif Med 1957;87:412–5.
Stearns MW, Grodsky L, Harrison EG Jr, Quan S, Rob CG. Malignant anal lesions (panel discussion). Dis Colon Rectum 1966;9:315–27.
Graham JH, Halwig EB. Bowen's disease and its relationship to systematic caner. Arch Dermatol 1961;83:738–51.
Arbesman H, Ransohoff DF. Is Bowen's disease a predictor for the development of internal malignancy? A methological critique of the literature. JAMA 1987;257:516–8.
Marfing TE, Abel ME, Gallagher DM. Perianal Bowen's disease and associated malignancies: results of a survey. Dis Colon Rectum 1987;30:728–5.
Wade TR, Kopf AW, Ackerman B. Bowenoid papulosis of the genitalia. Arch Dermatol 1979;11:306–8.
Glotzer DJ. The risk of cancer in Crohn's disease. Gastroenterology 1985;89:438–40.
Greenstein AJ, Gennuso R, Sacher DB, et al. Extraintestinal cancers in inflammatory bowel disease. Cancer 1985;56:2914–21.
Meyers S, Sachar DB, Taub RN, Janowitz HD. Anergy to dimitro chlorobenzine and depression of T-lymphocytes in Crohn's disease and ulcerative colitis. Gut 1987;17:911–5.
Heimann T, Gelernt I, Schanzer H, et al. Surgical treatment, skin test reactivity and lymphocytes in inflammatory bowel disease. Am J Surg 1983;145:199–201.
Beeken WL, MacPherson BR, Gundel RM, St. Andre-Ukena S, Wood SG, Sylwester DL. Depressed spontaneous cell-mediated cytotoxicity in Crohn's disease. Clin Exp Immunol 1983;51:351–8.
Zachow KR, Ostrow RS, Bender M, et al. Detection of human papillomavirus DNA in anogenital neoplasms. Nature 1982; 300:771–3.
Ikenberg H, Gissmann L, Gross G, Grussendorf-Conen EI, ZurHausen H. Human papillomavirus Type-16-related DNA in genital Bowen's disease and in Bowenoid papulosis. Int J Cancer 1983;32:563–5.
Penn I. Cancers of the anogenital region in renal transplant recipients. Cancer 1986;58:611–6.
Author information
Authors and Affiliations
Additional information
The opinions expressed are those of the authors and do not reflect the opinions of the United States Air Force or the Department of Defense.
About this article
Cite this article
Beck, D.E., Harford, F.J. & Roettger, R.H. Perianal Bowen's disease associated with Crohn's colitis. Dis Colon Rectum 32, 252–255 (1989). https://doi.org/10.1007/BF02554540
Issue Date:
DOI: https://doi.org/10.1007/BF02554540