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Prognostic factors in rectal carcinoma

A contribution to the further development of tumor classification

  • Published:
Diseases of the Colon & Rectum

Abstract

In 597 patients with adenocarcinoma or mucinous adenocarcinoma of the rectum, the prognosis after radical resection for cure was investigated. Staging according to the fourth edition of the UICC TNM classification showed a good correlation to prognosis. By multivariate analysis, various additional independent prognostic factors could be demonstrated. The individual additional prognostic factors are partly of significance in some pTNM defined stages and substages, but not in others. In order to obtain the most detailed knowledge of prognostic factors after radical resection for cure, multivariate analysis of prognostic factors in colorectal carcinoma must be performed not only in separate colonic and rectal groups, but also separately for each of the individual pTNM defined stages and substages.

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References

  1. UICC. TNM classification of malignant tumours. 4th ed. Hermanek P, Sobin LH. Berlin: Springer, 1987.

    Google Scholar 

  2. AJCC. Manual for staging of cancer. 3rd ed., Beahrs OH, Henson DE, Hutter RV, Myers MH. Philadelphia: J.B. Lippincott, 1988.

    Google Scholar 

  3. Hermanek P. Staging of colorectal cancer (symposium). Int J Colorect Dis 1987;2:123–38.

    Article  Google Scholar 

  4. Hermanek P. The new TNM/pTNM classification of colorectal carcinomas: what has changed and why? Coloproctology 1986; 10:6–12.

    Google Scholar 

  5. Hutter RV, Sobin LH. A universal staging system for cancer of the colon and rectum. Arch Pathol Lab Med 1986;110:367–8.

    PubMed  CAS  Google Scholar 

  6. Hutter RV, Sobin LH: Universal staging system for colorectal cancer: in reply. Arch Pathol Lab Med 1987;111:312–4.

    Google Scholar 

  7. Arnott SJ. Prognostic indices in colorectal cancer. In: Stoll BA, ed. Pointers to cancer prognosis. Dordrecht: Martinus Nijhoff, 1987.

    Google Scholar 

  8. Hermanek P. Prognostic value of the TNM system. In: Lapis K, Eckhardt S, eds. Lectures and symposia of the 14th International Cancer Congress. Budapest: Akademiai Kiadó, 1987, vol 3.

    Google Scholar 

  9. Fielding LP. Clinical-pathological staging of large-bowel cancer: a report of the ASCRS Committee. Dis Colon Rectum 1988;31: 204–9.

    PubMed  CAS  Google Scholar 

  10. Fielding LP, Fry SJ, Philips RK, Hittinger R. Predictive outcome after curative resection for large bowel cancer. Lancet 1986;2: 904–7.

    Article  PubMed  CAS  Google Scholar 

  11. Hermanek P. Klinische Krebsforschung. In: Gall FP, Hermanek P, Tonak J, eds. Chirurgische Onkologie. Berlin: Springer, 1986.

    Google Scholar 

  12. Stoll BA. Preface. In: Stoll BA, ed. Pointers to cancer prognosis. Dordrecht: Martinus Nijhoff, 1987.

    Google Scholar 

  13. Guggenmoos-Holzmann I, Hermanek P. Multivariate analyse der Therapie ergenbnisse bei kolorektalen karzinomen. In: Hermanek P, ed. Bedeutung des TNM-systems für die klinische onkologie München: Zuckschwerdt 1986.

    Google Scholar 

  14. Chapuis PH, Dent OF, Fisher R, et al. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 1985;72:698–702.

    PubMed  CAS  Google Scholar 

  15. Goh HS, Goh CR, Rauff A, Foong WC. Clinico-pathological prognostic factors of large bowel cancer in Singapore: a multivariate analysis. Ann Acad Med Singapore 1987;16:437–40.

    PubMed  CAS  Google Scholar 

  16. Griffin MR, Bergstralh EJ, Coffey RJ, Beart RW Jr., Melton LJ. Predictors of survival after curative resection of carcinoma of the colon and rectum. Cancer 1987;60:2318–24.

    Article  PubMed  CAS  Google Scholar 

  17. Hannisdal E, Thorsen G. Regression analyses of prognostic factors in colorectal cancer. J Surg Oncol 1985;37:109–12.

    Google Scholar 

  18. Maruoka V, Maetani S, Tobe T. Statistical analysis of pathological factors influencing prognosis of colorectal carcinoma. Nippon Geka Gakkai Zarski 1988;89:181–91.

    CAS  Google Scholar 

  19. Schmitz-Moormann P, Himmelmann GW, Baum U, Nilles W Morphological predictors of survival in colorectal carcinoma: univariate and multivariate analysis. J Cancer Res Clin Oncol 1987;113:586–92.

    Article  PubMed  CAS  Google Scholar 

  20. Steinberg SM, Barwick KW, Stablein DM. Improtance of tumor pathology and morphology in patients with surgically resected colon cancer. Cancer 1986;58:1340–5.

    Article  PubMed  CAS  Google Scholar 

  21. Wiggers T, Arends JW, Schutte B, Valovics L, Bosman FT. A multivariate analysis of pathologic prognostic indicators in large bowel cancer. Cancer 1988;61:386–95.

    Article  PubMed  CAS  Google Scholar 

  22. Freedman LS, Macaskill P, Smith AN. Multivariate analysis of prognostic factors for operable rectal cancer. Lancet 1984;2: 733–6.

    Article  PubMed  CAS  Google Scholar 

  23. Jass JR, Love SB, Northover JM. A new prognostic classification of rectal cancer. Lancet 1987;1:1303–6.

    Article  PubMed  CAS  Google Scholar 

  24. Minski BD, Mies C, Recht A, Rich TA, Chaffey JT. Resectable adenocarcinoma of the rectosigmoid and rectum. Cancer 1988; 61:1408–24.

    Article  Google Scholar 

  25. Quirke P, Dixon M, Clayden AD, et al. Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinoma. J Pathol 1987;151:285–91.

    Article  PubMed  CAS  Google Scholar 

  26. Hermanek P. Pathohistologische Begutachtung von Tumoren. Erlangen: Perimed, 1983.

    Google Scholar 

  27. Hermanek P, Altendorf A. Classification of colorectal carcinoma with regional lymphatic metastases. Path Res Pract 1981;173: 1–11.

    PubMed  CAS  Google Scholar 

  28. Morson BC, Sobin LH. Histological typing of intestinal tumours. Geneva: WHO, 1976.

    Google Scholar 

  29. Hermanek P. Prognostische Bedeutung des Differenzierungsgrades bei kolorektalem Karzinom. Verh Dtsch Ges Pathol 1986;70:408.

    Google Scholar 

  30. Cox DR. Regression models and life tables (with discussion) J R Stat Soc [B] 1972;34:187–220.

    Google Scholar 

  31. Guggenmoos-Holzmann I, Heinen B. Die Kodierung kategorialer Variabler in Regressionsmodellen. In: Lehmacher W, Hörmann A, eds. Proceedings der 3. Konferenz über die wissenschaftliche Anwendung von Statistik-Software. Stuttgart: G. Fischer, 1985.

    Google Scholar 

  32. Makuch RW. Adjusted survival curve estimation using covariates. J Chron Dis 1982;35:437–43.

    Article  PubMed  CAS  Google Scholar 

  33. Hermanek P. Gastric carcinoma—precancerous conditions and lesions, classification, and prognosis. In: Hotz J, Meyer HJ, Schmoll HJ, eds. Gastric carcinoma. New York: Springer, 1988.

    Google Scholar 

  34. Hermanek P, Guggenmoos-Holzmann I. Multivariate analysis of prognosis following curative tumor resection of stomach carcinoma. Proc 4th European Conference on Clinical Oncology (ECCO-4), Abstract 121, 1987.

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Authors and Affiliations

  1. Department of Surgical Pathology, University of Erlangen, Maximiliansplatz, D 8520, Erlangen, Federal Republic of Germany

    Paul Hermanek M.D.

  2. Department of Medical and Statistical Information, Free University, Berlin, Federal Republic of Germany

    Irene Guggenmoos-Holzmann M.D.

  3. Department of Surgery, University of Erlangen, Federal Republic of Germany

    Franz P. Gall M.D.

Authors
  1. Paul Hermanek M.D.
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  2. Irene Guggenmoos-Holzmann M.D.
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  3. Franz P. Gall M.D.
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Additional information

Read at the XIIth Biennial Congress of the International Society of University Colon and Rectal Surgeons, Glasgow, Scotland, July 10 to 14, 1988.

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Hermanek, P., Guggenmoos-Holzmann, I. & Gall, F.P. Prognostic factors in rectal carcinoma. Dis Colon Rectum 32, 593–599 (1989). https://doi.org/10.1007/BF02554180

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