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The effect of glucagon and glucagon 1–21 on anal sphincter function

  • Published:
Diseases of the Colon & Rectum

Abstract

Resting anal sphincter pressure and rectoanal reflex were studied in six healthy volunteers after administration of placebo, glucagon, and glucagon 1–21. Glucagon resulted in a marked but short-lived early decrease in resting anal pressure, whereas the 1–21 fragment of the glucagon molecule had no effect. Further investigation of the possible hormonal/peptidergic regulation of anal sphincter function is necessary.

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Authors and Affiliations

  1. Department of Surgery D, Glostrup Hospital, University of Copenhagen, DK-2600, Copenhagen, Denmark

    Ib Krogh Pedersen M.D. &  John Christiansen M.D., Ph.D.

Authors
  1. Ib Krogh Pedersen M.D.
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  2. John Christiansen M.D., Ph.D.
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Pedersen, I.K., Christiansen, J. The effect of glucagon and glucagon 1–21 on anal sphincter function. Dis Colon Rectum 28, 235–237 (1985). https://doi.org/10.1007/BF02554041

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  • DOI: https://doi.org/10.1007/BF02554041

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