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T-antigen expression by peanut agglutinin staining relates to mucosal dysplasia in ulcerative colitis

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Diseases of the Colon & Rectum

Abstract

Staining of 326 rectal mucosal biopsies from ulcerative colitis patients with peanut agglutinin (PNA), which binds to the T-blood group antigen and has been claimed to reflect a cancer-associated mucin alteration, showed highly significant direct associations with mucosal dysplasia (P<0.001), disease activity (P<0.001), and subsequent development of rectal cancer in a smaller series of patients (P=0.005). Staining for normal colonic mucin by theDolichos biflorus (DBA) lectin related significantly and inversely to dysplasia. Intense normal colon mucin staining by DBA related significantly (P<0.025) to long disease duration and to subsequent development of cancer (P=0.02). The latter association is based on a small number of patients only and is not considered conclusive evidence, but may provide a link with goblet-cell hyperplasia. The authors conclude that although T-antigen expression relates to dysplasia, the findings of “false” positive and negative rates of 22 and 33 percent respectively, make it unlikely that staining of biopsy sections for the T-antigen by peanut agglutinin will contribute materially to routine assessment for dysplasia and cancer risk prediction in patients with ulcerative colitis.

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Authors and Affiliations

  1. Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, Commercial Road, Prahran, 3181, Victoria, Australia

    Eric Pihl M.D., Anita Peura B.Sc. Hons., William R. Johnson M.D., Francis T. McDermott M.D. & Edward S. R. Hughes M.D.

  2. Department of Surgery, Monash University Medical School, Melbourne, Australia

    Eric Pihl M.D., Anita Peura B.Sc. Hons., William R. Johnson M.D., Francis T. McDermott M.D. & Edward S. R. Hughes M.D.

Authors
  1. Eric Pihl M.D.
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  2. Anita Peura B.Sc. Hons.
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  3. William R. Johnson M.D.
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  4. Francis T. McDermott M.D.
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  5. Edward S. R. Hughes M.D.
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Supported by a grant from the Alfred Hospital.

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Pihl, E., Peura, A., Johnson, W.R. et al. T-antigen expression by peanut agglutinin staining relates to mucosal dysplasia in ulcerative colitis. Dis Colon Rectum 28, 11–17 (1985). https://doi.org/10.1007/BF02553898

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  • DOI: https://doi.org/10.1007/BF02553898

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