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Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis

Report of a case

  • Published:
Diseases of the Colon & Rectum

Abstract

A 48-year-old man with Gardner's syndrome, who had abdominoperineal resection for rectal carcinoma in 1962, was found to have an ulcerating growth of the duodenum, and pancreaticoduodenectomy was performed in 1979. Histologic examination by complete step-serial sectioning disclosed a well-differentiated adenocarcinoma with adenomatous remnants, a large adenoma with focal carcinoma, 256 adenomas of the duodenum, and 91 adenomas of the gastric antrum. The world medical literature was reviewed, and 29 cases of periampullary carcinoma and 12 cases of gastric carcinoma complicating familial polyposis coli or Gardner's syndrome were analyzed.

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References

  1. Gardner EJ, Richards RS. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 1953;5:139–47.

    PubMed  CAS  Google Scholar 

  2. Bussey HJ. Extracolonic lesions associated with polyposis coli. Proc R Soc Med 1972;65:294.

    PubMed  CAS  Google Scholar 

  3. Cabot RC. Case records of the Massachusetts General Hospital: Case 21061. N Engl J Med 1935;212:263–7.

    Article  Google Scholar 

  4. Iida M. Extracolonic tumor-like lesions in familial polyposis coli and Gardner's syndrome (Japanase). Fukuoka J Med 1978;69:196–200.

    Google Scholar 

  5. Yao T, Iida M, Ohsato K, Watanabe H, Omae T. Duodenal lesions in familial polyposis of the colon. Gastroenterology 1977;73:1086–92.

    PubMed  CAS  Google Scholar 

  6. Utsunomiya J, Maki T, Iwama T, et al. Gastric lesion of familial polyposis coli. Cancer 1974;34:745–54.

    Article  PubMed  CAS  Google Scholar 

  7. Ushio K, Hirota E, Ichikawa H, et al. Gastric and duodenal lesions associated with familial polyposis coli (Japanese). Stomach Intestine 1977;12:1547–57.

    Google Scholar 

  8. Welch CE, Hedberg SE. Polypoid lesions of the gastrointestinal tract. Major Probl Clin Surg 1975;2:1–215.

    PubMed  CAS  Google Scholar 

  9. Jackman RJ, Beahrs OH. Tumors of the large bowel. Major Probl Clin Surg 1969;8:1–379.

    Google Scholar 

  10. Bussey HJ. Familial polyposis coli: family studies, histopathology, differential diagnosis, and results of treatment. Baltimore: Johns Hopkins University Press, 1975.

    Google Scholar 

  11. Hughes ES, Hueston JT. Desmoid tumor in familial polyposis of the colon: report of a case. Aust NZ J Surg 1960;30:131–9.

    CAS  Google Scholar 

  12. MacDonald JM, Davis WC, Crago HR, Berk AD. Gardner's syndrome and periampullary malignancy. Am J Surg 1967;113:425–30.

    Article  PubMed  CAS  Google Scholar 

  13. Capps WF Jr, Lewis MI, Gazzaniga DA. Carcinoma of the colon, ampulla of Vater and urinary bladder associated with familial multiple polyposis: a case report. Dis Colon Rectum 1968;11:298–305.

    PubMed  Google Scholar 

  14. McFarland PH Jr, Scheetz WL, Knisley RE. Gardner's syndrome: report of two families. J Oral Surg 1968;26:632–8.

    PubMed  Google Scholar 

  15. Duncan BR, Dohner VA, Priest JH. The Gardner syndrome: need for early diagnosis. J Pediatr 1968;72:497–505.

    Article  PubMed  CAS  Google Scholar 

  16. Parks TG, Bussey HJ, Lockhart-Mummery HE. Familial polyposis coli associated with extracolonic abnormalities. Gut 1970;11:323–9.

    PubMed  CAS  Google Scholar 

  17. Coli Moore JP, La Marche PH, DeLuca FG, Thayer WR Jr. Gardner's syndrome: a revisit to a previously described family. Dig Dis Sci 1970;15:551–68.

    Article  Google Scholar 

  18. Melmed RN, Bouchier IA. Duodenal involvement in Gardner's syndrome. Gut 1972;13:524–7.

    PubMed  CAS  Google Scholar 

  19. Schnur PL, David F, Brown PW Jr, Beahrs OH, ReMine WH, Harrison EG Jr. Adenocarcinoma of the duodenum and the Gardner syndrome. JAMA 1973;223:1229–32.

    Article  PubMed  CAS  Google Scholar 

  20. Mir-Madjlessi SH, Farmer RG, Hawk WA, Turnbull RB Jr. Adenocarcinoma of the ampulla of vater associated with familial polyposis coli: report of a case. Dis Colon Rectum 1973;16:542–6.

    PubMed  CAS  Google Scholar 

  21. Jones TR, Nance FC. Periampullary malignancy in Gardner's syndrome. Ann Surg 1977;185:565–73.

    Article  PubMed  CAS  Google Scholar 

  22. Watne AL, Core SK, Carrier JM. Gardner's syndrome. Surg Gynecol Obstet 1975;141:53–6.

    PubMed  CAS  Google Scholar 

  23. Carter BN. Discussion Ann Surg 1977;185:571–3.

    Google Scholar 

  24. Richardson JD. Discussion. Ann Surg 1977;185:572–3.

    Article  Google Scholar 

  25. Qizilbash AH. Familial polyposis coli and perimapullary carcinoma. Can J Surg 1976;19:166–8.

    PubMed  CAS  Google Scholar 

  26. Clarke DN, Smith JA, Norman JN, Brunt PW. Pancreatitis and duodenal obstruction due to periampullary carcinoma associated with familial polyposis coli. Postgrad Med J 1978;54:418–20.

    Article  PubMed  CAS  Google Scholar 

  27. Murphy ES, Mireles M, Beltrán A. Familial polyposis of the colon and gastric carcinoma: concurrent conditions in a 16-year-old boy. JAMA 1962;179:1026–8.

    PubMed  CAS  Google Scholar 

  28. Yamada S, Takahashi T. Familial polyposis coli (Japanese). Jap J Can Clin 1971;17:676–86.

    CAS  Google Scholar 

  29. Ito H, Ohsato K, Kamata M, Tamesue N, Nishimura M, Watanabe E. Diffuse polyposis of the colon (Japanese). Jap J Can Clin 1973;19:215–22.

    Google Scholar 

  30. Nishida K, Tomita T, Horie H, Sawano Y, Moriya T, Hunahiki T. Gardner's syndrome associated with gastric cancer (Japanese). Stomach Intestine 1974;9:1157–64.

    Google Scholar 

  31. Aoki N, Fuziwara M, Iwama T, Utsunomiya J. Gastric lesions of familial polyposis coli (Japanese). Stomach Intestine 1975;10:361–8.

    Google Scholar 

  32. Ohiwa T, Watanabe E. Report of a case of familial adenomatosis coli associated with gastric carcinoma (Japanese). Stomach Intestine 1978;13:1105–11.

    Google Scholar 

  33. Kimura H, Iizima T, Nakamura T. A case report of familial polyposis coli associated with gastric lesions (Japanese). J Jap Soc Colo-proctol 1978;31:284.

    Google Scholar 

  34. Funkenstein O. Ueber Polyposis intestinalis. Z Klin Med 1904;55:536–48.

    Google Scholar 

  35. Halsted JA, Harris EJ, Bartlett MK. Involvement of the stomach in familial polyposis of the gastro-intestinal tract: report of a family. Gastroenterology 1950;15:763–70.

    PubMed  CAS  Google Scholar 

  36. Pollack JL, Swinton NW. Congenital polyposis of the colon with extension to the small intestine and stomach. Lahey Clin Found Bull 1955;9:174–9.

    CAS  Google Scholar 

  37. Gumpel RC, Carballo JD. A new concept of familial adenomatosis. Ann Intern Med 1966;45:1045–58.

    Google Scholar 

  38. Kaplan BJ. Gardner's syndrome: heredofamilial adenomatosis associated with “soft and hard” fibrous tumors and epidermoid cysts. Dis Colon Rectum 1961;4:252–62.

    PubMed  CAS  Google Scholar 

  39. Boley SJ, McKinnon WM, Marzulli VF. The management of familial gastrointestinal polyposis involving stomach and colon. Surgery 1961;50:691–6.

    PubMed  CAS  Google Scholar 

  40. Hori K, Murakami E, Nagatomo T, et al. Gardner's syndrome (Japanese). Stomach Intestine 1968;3:211–7.

    Google Scholar 

  41. Martel AJ, Bonanno CA. Multiple polyposis of the gastrointestinal tract with osteoma and soft tissue tumors. Am J Dig Dis 1968;13:588–91.

    Article  PubMed  CAS  Google Scholar 

  42. Yonemoto RH, Slayback JB, Byron RL Jr, Rosen RB. Familial polyposis of the entire gastrointestinal tract. Arch Surg 1969;99:427–34.

    PubMed  CAS  Google Scholar 

  43. Hoffmann DC, Goligher JC. Polyposis of the stomach and small intestine in association with familial polyposis coli. Br J Surg 1971;58:126–8.

    PubMed  CAS  Google Scholar 

  44. Keshgegian AA, Enterline HT. Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary-follicular adenocarcinoma. Dis Colon Rectum 1978;21:255–60.

    PubMed  CAS  Google Scholar 

  45. Sasaki Y, Kozima H, Tsunemi S, Fuzita Y, Mazima S. Adenomatous polyp of the ampulla of Vater associated with familial polyposis coli (Japanese). Jap J Gastroenterol 1980;13:456–68.

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University of Tokyo, 7-3-1 Hongo Bunkyo-Ku, 113, Tokyo, Japan

    Kenichi Sugihara, Tetsuichiro Muto, Junjiro Kamiya, Fumio Konishi, Toshio Sawada & Yasuhiko Morioka

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  1. Kenichi Sugihara
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  2. Tetsuichiro Muto
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  3. Junjiro Kamiya
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  4. Fumio Konishi
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  5. Toshio Sawada
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  6. Yasuhiko Morioka
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Sugihara, K., Muto, T., Kamiya, J. et al. Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis. Dis Colon Rectum 25, 766–771 (1982). https://doi.org/10.1007/BF02553308

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  • DOI: https://doi.org/10.1007/BF02553308

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