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New occlusive agent for therapeutic embolization tested in dogs

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Abstract

A new occlusive agent, Vilan 500, was used to embolize the arterial bed of the kidney in 12 dogs. This polyvinyl acetate, alcohol-soluable agent becomes gelantinous on contact with an aqueous environment and its low viscosity makes this material well suited for application through small-caliber catheters. Complete arterial occlusion of the embolized kidneys was observed in all animals. On histologic examination of tissue 4–6 weeks after the procedure, changes were seen such as shrinkage through fibrosis, diffuse necrosis and atrophic parenchyma. No signs of recanalization of the embolized artery or functional collateral circulation were noted in any dog.

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Authors and Affiliations

  1. Department of Radiology, Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia

    Jan H. Peregrin

  2. Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

    Miroslav Kašpar

  3. Institute of Pathological Anatomy II, Charles University Medical Faculty, Prague, Czechoslovakia

    Rudolf Vaněček

  4. Transplantation Research Centre, Institute for Clinical and Experimental Medicine, Vídeňská 800 146 22, Prague 4, Czechoslovakia

    Milan Haco & Alfred Belán

Authors
  1. Jan H. Peregrin
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  2. Miroslav Kašpar
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  3. Milan Haco
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  4. Rudolf Vaněček
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  5. Alfred Belán
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Peregrin, J.H., Kašpar, M., Haco, M. et al. New occlusive agent for therapeutic embolization tested in dogs. Cardiovasc Intervent Radiol 7, 97–101 (1984). https://doi.org/10.1007/BF02552689

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  • DOI: https://doi.org/10.1007/BF02552689

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