Abstract
Arterial thrombolysis was successfully accomplished in 15 of 18 (83%) cancer patients by the continuous intraarterial transcatheter administration of streptokinase (70 units/kg/h or 5000 u/h and/or urokinase (400–500 u/kg/h) over 24–96 h. In 16 of these patients, the arterial thrombosis was a complication of transcatheter infusion of chemo-therapeutic agents or embolization therapy. A combination of streptokinase, urokinase and heparin (10,000–25,000 U/day) was utilized without significant side effect and was effective in all 8 patients receiving treatment. Creating a tunnel through the clot, daily monitoring of the catheter with repositioning when necessary, and adjusting the type and dose of thrombolytic agent aided the therapeutic management.
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Kudo, S., Chuang, V.P., Wallace, S. et al. Transcatheter thrombolysis in cancer patients. Cardiovasc Intervent Radiol 8, 1–7 (1985). https://doi.org/10.1007/BF02552632
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DOI: https://doi.org/10.1007/BF02552632