Abstract
An animal model was proposed to clarify the difference in occurrence of enterocolitis in congenital aganglionosis. When gaseous distention of the colon was localized to the rectosigmoid area, enterocolitis never occurred. On the contrary, when it involved the left colon, enterocolitis occurred in 13 of 15 patients. Intestinal blood flow rates were simultaneously measured in the left colon and rectum of six dogs by using labeled microspheres and expressed in function of the intraluminal pressure. Results show that for elevated values of intraluminal pressure, blood flow was significantly lower in the left colon than in the rectum. These results may explain why ischemia and necrosis occurred more frequently in the left colon than in the rectum.
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Arhan, P., Bouchoucha, M., Martelli, H. et al. Relationship between parietal blood flow studies in the left colon and the rectum in dogs. Dis Colon Rectum 31, 54–57 (1988). https://doi.org/10.1007/BF02552571
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DOI: https://doi.org/10.1007/BF02552571