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The therapy of osteosarcoma by intraarterial cis-platinum and limb preservation

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Abstract

Intraarterial infusion of cis-platinum was evaluated in 14 patients with primary osteosarcoma because the method delivers a higher dose to the neoplasm without increasing systemic toxicity. The tumor response was evaluated by clinical examination, conventional radiography, angiography, and histopathologic examination. Eight (57%) of the 14 patients responded. Among the eight responders, four patients with medullary osteosarcoma of the extremities were treated by limb salvage operation followed by insertion of an endoprosthesis to preserve limb function. The responders are all alive with a median follow-up period of 17.5 months; six of them have no evaluable disease. The six failures died of disease after median survival of 6.5 months. Intraarterial cis-platinum infusion proved to be an effective approach in treating osteosarcoma and created the opportunity for limb salvage.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, 77030, Houston, TX, USA

    Vincent P. Chuang M.D., Sidney Wallace, Jesus Zornoza, Chusilp Charnsangavej & Chiu-Shiung Soo

  2. Department of Developmental Therapeutics, The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, 6723 BertnerAvenue, Houston, Texas, USA

    Robert S. Benjamin, Yehuda Patt & Giora Mavligit

  3. Department of Pediatrics, The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, 6723 BertnerAvenue, Houston, Texas, USA

    Norman Jaffe

  4. Department of Pathology, The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, 6723 BertnerAvenue, Houston, Texas, USA

    Alberto Ayala

  5. Department of Surgery, The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, 6723 BertnerAvenue, Houston, Texas, USA

    John Murray

Authors
  1. Vincent P. Chuang M.D.
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  2. Sidney Wallace
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  3. Robert S. Benjamin
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  4. Norman Jaffe
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  5. Alberto Ayala
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  6. John Murray
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  7. Jesus Zornoza
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  8. Yehuda Patt
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  9. Giora Mavligit
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  10. Chusilp Charnsangavej
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  11. Chiu-Shiung Soo
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Chuang, V.P., Wallace, S., Benjamin, R.S. et al. The therapy of osteosarcoma by intraarterial cis-platinum and limb preservation. Cardiovasc Intervent Radiol 4, 229–235 (1981). https://doi.org/10.1007/BF02552525

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