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Nitrofurantoin versus Trimethoprim for low-dose long-term prophylaxis in patients with recurrent urinary tract infections

A prospective randomized study

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Abstract

In a prospective randomized study 38 patients with recurrent urinary tract infections (rUTI) were included to take either 50 mg Nitrofurantoin (n=19) or 50 mg Trimethoprim (n=19) as low-dose long-term prophylaxis for half a year. Compliance was checked weekly byBacillus subtilis spore test strips sent in by mail. The infection rate was reduced from more than three per patient year to 0.01. There were no significant differences between the two groups concerning the recurrence rate (Nitrofurantoin: one rUTI; Trimethoprim: three rUTI) or side effects. Under Nitrofurantoin treatment 3 symptomatic fungal infections occurred. Trimethoprim and Nitrofurantoin are equally suitable for low-dose long-term prophylaxis in rUTI. Surveillance of compliance gives important hints for failure of prophylaxis.

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References

  1. Bailey, R. R., Roberts, A. P., Gower, P. E., DeWardener, H. E.: Prevention of urinary tract infection with low dose Nitrofuratoin.Lancet, 2, 1112 (1971).

    Article  PubMed  CAS  Google Scholar 

  2. Breithaupt, H: Grundlagen der Chemoprophylaxe unter besonderer Berücksichtigung von Trimethoprim und Nitrofurantoin aus klinisch-pharmakologischer Sicht.Aktuel. Urol., 18, Suppl. 1, 2 (1987).

    Google Scholar 

  3. Brillinger, G. U., Steinhausen, R. L., Supka, R., Wieczorek, L. R., Wielinger, H.: Personal communication.

  4. Furadantin, Wissenschaftliche Informationsschrift Röhm Pharm, Darmstadt.

  5. Huland, H.: Chemoprophylaxe bei Frauen mit rezidivierenden Harnwegsinfektionen.Aktuel. Urol., 18, Suppl. 1, 19 (1987).

    Article  Google Scholar 

  6. Kaltwasser, F., Kaltwasser, G., Banauch, D., Wieczorek, L.: Nachweis antibakterieller Substanzen im Harn mit Teststreifen.Münch. Med. Wochenschr., 125, 694 (1983).

    CAS  Google Scholar 

  7. Kollegium Biomathematik. Springer, Berlin-heidelberg-New York 1977.

  8. O'Grady, F., Kelsey, I., McSherry, A., Cattell, W. R.: Long-term treatment of persistent or recurrent urinary tract infection with Trimethoprim-Sulfamethoxazole.J. Infect. Dis., 128, Suppl. S652 (1973).

    PubMed  Google Scholar 

  9. Schäfer, V., Weidner, W., Schiefer, H. G., Knothe, H.: Resistenzentwicklung unter Chemoprophylaxe mit Trimethoprim und Cotrimoxazol bei der rezidivierenden, unkomplizierten E. coli Harnwegsinfektion der Frau.Aktuel. Urol., 18, Suppl. 1, 23 (1987).

    Google Scholar 

  10. Stamey, T. A., Condy, M., Mihara, G.: Prophylactic efficacy of Nitrofurantoin macrocrystals and trimethoprim-sulfamethoxazole in urinary infections.N. Engl. J. Med., 296, 780 (1977).

    Article  PubMed  CAS  Google Scholar 

  11. Trimono, Wissenschaftliche Informationsschrift. Röhm Pharma, Darmstadt.

  12. Weidner, W., Weißbach, L., Eickenberg, H.-U., Carl, P., Meyer, W.: Trimethoprim und Cotrimoxazol zur Prophylaxe der rezidivierenden unkomplizierten Harnwegsinfektionen der Frau.Urologe [B],25, 124 (1985).

    Article  Google Scholar 

  13. Westenfelder, M., Pelz, K., Frankenschmidt, A., Vahlensieck, W.: Klinische Prüfung der Effektivität und Verträglichkeit von Norfloxacin in der Therapie komplizierter Harnwegsinfektionen und in der Langzeitprophylaxe rezidivierender Harnwegsinfektionen.Infection, 15, 20 (1987).

    Article  PubMed  CAS  Google Scholar 

  14. Westenfelder, M., Vahlensieck, W., Reinarz, U.: Efficacy of and compliance with low-dose long-term prophylaxis in patients with recurrent urinary tract infections. Proc. IVth Intern. Pyelonephritis Symposium, Göteborg, 1986. University Press, Chicago 1987, pp. 422–425.

    Google Scholar 

  15. Westenfelder, M., Vahlensieck, W., Reinarz, U.: Patient complicance and efficacy of low-dose, long-term prophylaxis in patients with recurrent urinary tract infections. Proc. Vth Mediterranean Congress of Chemotherapy, Cairo 1986.Chemiotherapia, 6, Suppl. 2, 530 (1987).

    CAS  Google Scholar 

  16. Westenfelder, M., Vahlensieck, W., Reinarz, U.: Patientencompliance und Effektivität der antimikrobiellen Langzeiprophylaxe mit Niedrigdosen bei Patienten mit rezidivierenden harnwegsinfektionen (rHWI).Aktuel. Urol., 18, 6 (1987).

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, University of München, Germany

    W. Vahlensieck Jr.

  2. Department of Urology, Maria Hilf Hospital Krefeld, Germany

    M. Westenfelder

  3. Department of Urology, University of Freiburg, Germany

    W. Vahlensieck Jr. & M. Westenfelder

Authors
  1. W. Vahlensieck Jr.
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  2. M. Westenfelder
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Vahlensieck, W., Westenfelder, M. Nitrofurantoin versus Trimethoprim for low-dose long-term prophylaxis in patients with recurrent urinary tract infections. International Urology and Nephrology 24, 3–10 (1992). https://doi.org/10.1007/BF02552109

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  • DOI: https://doi.org/10.1007/BF02552109

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