Skip to main content
SpringerLink
Log in

Assessment of regional myocardial blood flow using the inert gas washout technique

  • Published:
Cardiovascular radiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Anger, H.O.: Gamma-ray and positron scintillation camera. Nucleonics 21:56–68, 1963

    Google Scholar 

  2. Bassingthwaighte, J.B., Strandell, T., Donald, D.E.: Estimation of coronary blood flow by washout of diffusible indicators. Circ. Res. 23:259–278, 1968

    PubMed  CAS  Google Scholar 

  3. Bassingthwaighte, J.B.: Physiology and theory of tracer washout techniques for the estimation of myocardial blood flow: Flow estimation from tracer washout. Progr. Cardiovasc. Dis. 20:165–189, 1977

    Article  CAS  Google Scholar 

  4. Becker, L., Pitt, B.: Regional myocardial blood flow, ischemia and antianginal drugs. Ann. Clin. Res. 3:353–361, 1971

    PubMed  CAS  Google Scholar 

  5. Bretschneider, H.J., Cott, L., Hilgert, G., Probst, R., Rau, G.: Gaschromatographische Trennung und Analyse von Argon als Basis einer neuen Fremdgasmethode zur Durchblutungsmessung von Organen (abstract). Verh. dtsch. Ges. Kreislaufforschg. 32:267, 1966

    CAS  Google Scholar 

  6. Budinger, T.F., Rollo, F.D.: Physics and instrumentation. Progr. Cardiovasc. Dis. 20:19–53, 1977

    Article  CAS  Google Scholar 

  7. Bunnell, T.L., Klocke, F.J., Greene, D.G., Arani, D., Tandon, R., Oliveros, R., Wittenberg, S.M.: Effects of isolated left anterior descending coronary artery stenosis on coronary blood flow (abstract). J. Clin. Invest. 53:13a, 1974

    Google Scholar 

  8. Cannon, P.J., Haft, J.I., Johnson, P.M.: Visual assessment of regional myocardial perfusion utilizing radioactive xenon and scintillation photography. Circulation 40:277–288, 1969

    PubMed  CAS  Google Scholar 

  9. Cannon, P.J., Weiss, M.B., Sciacca, R.R.: Myocardial blood flow in coronary artery disease: Studies at rest and during stress with inert gas washout techniques. Progr. Cardiovasc. Dis: 20:95–120, 1977

    Article  CAS  Google Scholar 

  10. Chidsey, C.A., Fritts, H.H., Hardewig, A.: Fate of radioactive krypton (Kr85) introduced intravenously in man. J. Appl Physiol. 14:63–68, 1959

    PubMed  CAS  Google Scholar 

  11. Cohen, L.S., Elliott, W.C., Gorlin, R.: Measurement of myocardial blood flow using krypton-85. Am. J. Physiol. 206:997–999, 1964

    PubMed  CAS  Google Scholar 

  12. Cohn, P.F., Maddox, D., Holman, B.L., Markis, J.E., Adams, D.F., See, J.R., Idione, J.: Effects of subliqually administered nitroglycerin on myocardial blood flow in patients with coronary artery disease. Am. J. Cardiol. 39:672–678, 1977

    Article  PubMed  CAS  Google Scholar 

  13. Conn, H.L.: Equilibrium distribution of radioxenon in tissue Xenon-hemoglobin association curve. J. Appl. Physiol. 16:1065–1070, 1961

    PubMed  CAS  Google Scholar 

  14. Dirschinger, J., Fleck, E., Redl, A., Brandt, R., Späth, M., Mannes, G., Recke, S., Hall, D., Rudolph, W.: Effects of sodium nitroprusside and isosorbiddinitrate on regional myocardial blood flow in patients with coronary artery disease and left ventricular asynergy. Herz 2:71–74, 1977

    Google Scholar 

  15. Dirschinger, J., Fleck, E., Rudolph, W.: Die Bedeutung der Herzfrequenzsenkung für die Wirkung von Betarezeptorenblockern bei koronarer Herzerkrankung (abstract). Z. Kardiol 67:227, 1978

    Google Scholar 

  16. Engel, H.J., Heim, R., Liese, W., Hundershagen, H., Lichtlen, P.: Regional myocardial perfusion at rest in coronary disease assessed by microsphere scintigraphy and intert gas clearance (abstract). Am. J. Cardiol. 37:134, 1976

    Article  Google Scholar 

  17. Engel, H.J., Hundeshagen, H., Lichtlen, P.: Transmural myocardial infarction in young women taking oral contraceptives Evidence of reduced regional ceronary flow in spite of normal coronary arteries. Br. Heart J. 39:477–484, 1977

    PubMed  CAS  Google Scholar 

  18. Engel, H.J.: Regionale Myokarddurchblutung Habilitation. Hannover 1977 (unpublisyhed data).

  19. Engel, H.J., Lichtlen, P.R., Hundeshagen, H.: Effects of coronary obstructions and segmental LV dysfunction on regional myocardial blood flow (abstract). Circulation 55/56: (Suppl. III) 10, 1977

    Google Scholar 

  20. Engel, H.J., Wolf, R., Hundeshagen, H., Lichtlen, P.: Einfluss von Nitroglyzerin auf die regionale Myokarddurchblutung bei Patienten mit pacing-induzierter Myokardischämie (abstract) Z. Kardiol. 68:283, 1979

    Google Scholar 

  21. Fleck, E., Dirschinger, J., Redl, A., Loracher, C., Hall, D., Froer, K.L., Rudolph, W.: Alterations in regional myocardial blood flow and ventricular function induced by betablocking agents and calcium antagonists in patients with coronary artery disease. Herz 2:75–80, 1977

    Google Scholar 

  22. Frick, M.H., Valle, M., Korhola, O.: Analysis of coronary collaterals in ischemic heart disease by angiography during pacing-induced ischemia. Br. Heart J. 38:186, 1976

    PubMed  CAS  Google Scholar 

  23. Goldberg, A.D., Crawley, J.C.W., Raftery, E.B., Yocoub, M.H.: Myocardial blood flow following saphenous vein bypass surgery. Circulation 51/52: (suppl. 1) 215–219, 1975

    Google Scholar 

  24. Gould, K.L., Lipscomb, K., Hamilton, G.W.: Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am. J. Cardiol. 33:87–94 1974

    Article  PubMed  CAS  Google Scholar 

  25. Gould, K.L., Lipscomb, K.: Effects of coronary stenoses on coronary flow reserve and resistance. Am. J. Cardiol. 34:48–55, 1974

    Article  PubMed  CAS  Google Scholar 

  26. Herd, J.A., Hollenberg, M., Thorburn, G.D., Kopald, H.H., Barcher, A.C.: Myocardial blood flow determined with krypton85 in unanesthetized dogs. Am. J. Physiol. 203:122–124, 1962

    PubMed  CAS  Google Scholar 

  27. Hirzel, H.O., Krayenbühl, H.P.: Vilidaty of the133Xenon method for measuring coronary blood flow: Comparison with coronary sinus outflow determined by an electromagnetic flow-probe. Pflueger's Arch 349:159–169, 1974

    Article  CAS  Google Scholar 

  28. Hoffman, J.I.E., Buckberg, G.D.: Transmural variations in myocardial perfusion. In: Progress in Cardiology, edited by P.N. Yu and J.F. Goodwin. Philadelpha, Lea & Febiger, 1976, pp. 37–89

    Google Scholar 

  29. Holman, B.L., Adams, D.F., Jewitt, D., Eldh, P., Idoine, J., Cohn, P.F., Gorlin, R., Adelstein, S.J.: Measuring regional myocardial blood flow with133Xe and the Anger camera. Radiology 112:99–107, 1974

    PubMed  CAS  Google Scholar 

  30. Holmberg, S., Serzysko, W., Varnauskas, E.: Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease. Acta Med. Scand. 190:465–480, 1971

    Article  PubMed  CAS  Google Scholar 

  31. Hundeshagen, H., Geisler, S., Dittmann, P., Lichtlen, P., Engel, H.J.: Quantitative scintigraphic display of myocardial blood flow: Technique and clinical evaluation. Eur. J. Nucl. Med. 1:107–115, 1976

    PubMed  CAS  Google Scholar 

  32. Kety, S.S., Schmidt, C.P.: The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am. J. Physiol. 143:53–66, 1945

    CAS  Google Scholar 

  33. Kety, S.S.: Theory and applications of exchange of inert gas at lungs and tissues. Pharmacol. Rev. 3:1–41, 1951

    PubMed  CAS  Google Scholar 

  34. Klocke, F.J., Rosing, D.R., Pittman, D.E.: Thert gas measurements of coronary blood flow. Am. J. Cardiol. 23:548–555, 1969

    Article  PubMed  CAS  Google Scholar 

  35. Klocke, F.J., Bunnell, I.L., Greene, D.G., Wittenberg, S.M., Visco, J.P.: Average coronary blood flow per unit weight of left ventricle in patients with and without coronary artery disease. Circulation 50:547–559, 1974

    PubMed  CAS  Google Scholar 

  36. Klocke, F.J.: Clinical measurements of coronary blood flow. In: Progress in Cardiology, edited by P.N. Yu and J.F. Goodwin. Philadelphia, Lea & Febiger, 1976, pp. 91–140

    Google Scholar 

  37. Korbuly, D.E., Formanek, A., Gypser, G., Moore, R., Ovitt, T.W., Tuna, N., Amplatz, K.: Regional myocardial blood flow measurements before and after coronary bypass surgery. Circulation 52:38–45, 1975

    PubMed  CAS  Google Scholar 

  38. Lassen, N.A.: Assessment of tissue radiation dose in clinical use of radioactive inert gases with examples of absorbed doses from 3-H, 83-Kr, 133-Xe. Minerva Nucl. 8:211–217, 1964

    Google Scholar 

  39. Lichtlen, P., Moccetti, T., Halter, J., Schönbeck, M., Senning, A.: Postoperative evaluation of myocardial blood flow in arortato-coronary artery vein bypass grafts using the xenon-residue detection technic. Circulation 46:445–455, 1972

    PubMed  CAS  Google Scholar 

  40. Lichtlen, P., Moccetti, T., Halter, J.: Myocardial blood flow in man as shown by the precordial xenon-clearance technique. In: Myocardial Blood Flow in Man: Methods and Significance in Coronary Disease, edited by A. Maseri. Torino. Minerva Medica. 1972, pp. 309–320

    Google Scholar 

  41. Lichtlen, P., Halter, J., Gattiker, K.: The effect of Isosorbiddinatrate on coronary flow, coronary resistance and left ventricular dynamics under exercise in patients with coronary artery disease. Basic Res. Cardiol. 69:402–421, 1974

    Article  PubMed  CAS  Google Scholar 

  42. Lichtlen, P.: Coronary and left ventricular dynamics under nifedipine in comparison to nitrates, betablocking agents and dipyridamole. In: Second International Adalat Symposium: New Therapy of Ischemic Heart Desiase, edited by W. Lochner, W. Braasch, and G. Kroneberg, Berlin, Heidelberg, New York, Springer, 1975, pp. 212–224

    Google Scholar 

  43. Lichtlen, P.R.: Myocardial blood flow during exercise in patients with coronary artery disease. Herz 2:31–37, 1977

    Google Scholar 

  44. Lichtlen, P., Engel, H.J., Hundeshagen, H.: Regional myocardial blood flow in normal and poststenotic areas after nitroglycerin, betablockade (atenolol), coronary dilatation (dipyridamole) and calcium antagonism (nifedipine). Herz 2:81–86, 1977

    Google Scholar 

  45. Lichtlen, P.R., Engel, H.J., Hundeshagen, H.: Clinical application and results of the assessment of coronary blood flow by the regional precordial xenon residue detection technique. Nucl. Med. 17:161–171, 1978

    CAS  Google Scholar 

  46. Lichtlen, P.R., Wolf, R., Engel, H.J., Hundeshagen, H.: Coronary dilatory reserve of severely obstructed coronary arteries and collaterals (abstract). Circulation 57/58:(Suppl. II) 193, 1978

    Google Scholar 

  47. Lichtlen, P.R., Engel, H.J.: Angiographic aspects of coronary heart disease in young women. In: Coronary Heart Disease in Young Women, edited by M.F. Oliver, Edinburgh, Churchill Livingstone, 1978, pp. 80–85

    Google Scholar 

  48. Lichtlen, P.R., Engel, H.J., Amende, I., Hundeshagen, H.: Effect of betablockade on regional myocardial blood flow in coronary heart disease. International Symposium on Betablockade, Manila, 1978 (in press)

  49. Lichtlen, P.R., Engel, H.J., Wolf, R., Amende, I.: The effect of the calcium antagnostic drug nifedipine on coronary and left ventricular dynamics in patients with coronary heart disease. Symposium on the Effect of Calcium-Antagonists, Frankfurt, 1978 (in press)

  50. McIntyre, W.J., Cannon, P.J., Ashburn, W.L.: Measurements of regional myocardial perfusion. In: Quantitative Nuclear Cardiology, edited by R.H. Pierson, J.P. Kriss and R.H. Jones, New York, John Wiley and Sons, 1975, p. 170.

    Google Scholar 

  51. Maddox, D.E., See, J.R., Holman, B.L., Adams, D.F., Cohn, P.F.: Effect of coronary collaterals on regional myocardial blood flow (abstract). Circulation 53/54: (Suppl. II) 231, 1976

    Google Scholar 

  52. Maseri, A., Mancini, P., L'Abbate, A.: Method for regional dynamic study of myocardial blood flow in man. J. Nucl. Biol. Med. 15:54–57, 1971

    PubMed  CAS  Google Scholar 

  53. Maseri, A.: Radioactive tracer techniques for evaluating coronary flow. In: Progress in Cardiology, edited by P.N. Yu and J.F. Goodwin, Philadelphia, Lea & Febiger, 1976, pp. 141–168

    Google Scholar 

  54. Maseri, A., L'Abbate, A., Pesola, A., Michelassi, C., Marzilli, M., De Nes, M.: Regional myocardial perfusion in patients with atherosclerotic coronary artery disease, at rest and during angina pectoris induced by tachycardia. Circulation 55:423–433, 1977

    PubMed  CAS  Google Scholar 

  55. Mösslacher, H., Slany, J., Imhof, H.: Correlation between coronary angiography and determination of regional myocardial perfusion in coronary patients using the xenon clearance. In: Coronary Angiography and Angina Pectoris, edited by P.R. Lichtlen, Stuttgart, Thieme, 1976, pp. 284–291

    Google Scholar 

  56. Nakamura, M., Matsuguchi, H., Mitsutake, A., Kikuchi, Y., Takeshita, A., Nakagaki, O., Kuroiwa, A.: The effect of graded coronary stenosis on myocardial blood flow and left ventricular wall motion. Basic. Res. Cardiol. 72:479–492, 1977

    Article  PubMed  CAS  Google Scholar 

  57. Pitt, A., Friesinger, G.C., Ross, R.S.: Measurement of blood flow in the right and left coronary artery bed in human and dogs using the133Xenon technique. Cardiovasc. Res. 3:100–106, 1969

    Article  PubMed  CAS  Google Scholar 

  58. Ross, R.S., Lichtlen, P.R., Bernstein, L., Ginn, W.M., Ueda, K.: Selective coronary arteriography in man: correlated with clinical electrocardiographic and physiological studies (abstract). Circulation 28:793, 1963

    Google Scholar 

  59. Ross, R.S., Ueda, K., Lichtlen, P.R., Rees, J.R.: Measurement of myocardial blood in animals and man by selective injection of radioactive inert gas into the coronary arteries. Circ. Res. 15:28–41, 1964

    PubMed  CAS  Google Scholar 

  60. Rudolph, W., Fleck, E., Dirschinger, J., Redl, A.: Regional myocardial blood flow determined by the133Xenon washout technique with respect to coronary artery stenoses and wall motion abnormalities. Herz 2:16–22, 1977

    Google Scholar 

  61. Selwyn, A., Fox, K., Forse, G., Steiner, R.: Disturbances of regional myocardial perfusion in patients with coronary artery disease (abstract). Am. J. Cardiol. 43:423, 1979

    Google Scholar 

  62. Shaw, D.J., Pitt, A., Friesinger, G.C.: Autoradiographic study of the133Xenon disappearance method for measurement of myocardial blood flow. Cardiovasc. Res. 6:286–276, 1971

    Google Scholar 

  63. Tauchert, M., Kochsiek, K., Heiss, H.W., Strauer, B.E., Kettler, D., Reploh, H.D., Rau, G., Bretschneider, H.J. Measurement of coronary blood flow in man by the Argon method. In: Myocardial Blood Flow in Man. Methods and Significance in Coronary Disease, edited by A. Maseri. Torino, Minerva Medica, 1972, pp. 139–144

    Google Scholar 

  64. Weiss, E.S., Siegel, B.A., Sobel, B.E., Welch, M.J., Ter-Pogossian, M.M.: Evaluation of myocardial metabolism and perfusion with positron-emitting radionuclides. Progr. Cardiovasc. Dis. 20:191–206, 1977

    Article  CAS  Google Scholar 

  65. Winbury, M.M.: Experimental studies on the mechanism of action of nitrates and beta-adrenergic blockers. In: Pharmacologie Clinique des Médicaments Antiangieux, Symposium, Paris, 1974, Basel, Sandoz Editions, 1975, pp. 153–170.

    Google Scholar 

  66. Wolf, R., Engel, H.J., Hundeshagen, H., Lichtlen, P.: Collateral myocardial blood flow at rest and after maximal arteriolar dilatation in patients with ischemic heart disease. In: Coronary heart Disease, edited by M. Kaltenbach, P. Lichtlen, R. Balcon and W.D. Bussmann, Stuttgart, Thieme, 1978, pp. 61–65.

    Google Scholar 

  67. Wolf, R., Pretschner, B.P., Engel, H.J., Hundeshagen, H., Lichtlen, P.R.: Effect of Isosorbiddinitrate on201Thallium myocardial amaging in coronary heart disease (abstract). Am. J. Cardiol. 43:432, 1979

    Google Scholar 

  68. Wolfson, W., Heinle, R.A., Herman, M.V., Kemp, H.G., Sullivan, J.M., Gorlin, R.: Propranlol and angina pectoris. Am J. Cardiol. 18:346–353, 1966

    Article  Google Scholar 

  69. Wyatt, H.L., Forrester, J.S., Tyberg, J.V., Goldner, S., Logan, S.E., Parmley, W.W., Swan, H.J.C.: Effect of graded reductions in regional coronary perfusion on regional and total cardiac function. Am. J. Cardiol. 36:185–192, 1975

    Article  PubMed  CAS  Google Scholar 

  70. Zierler, K.L.: Equations for measuring blood flow by external monitoring of radioisotopes. Circ. Res. 16:309–321, 1965

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Karl-Wiechert Allee 9, D-3000, Hannover, Federal Republic of Germany

    P. R. Lichtlen (Director) & H. -J. Engel

Authors
  1. P. R. Lichtlen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. -J. Engel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lichtlen, P.R., Engel, H.J. Assessment of regional myocardial blood flow using the inert gas washout technique. Cardiovasc Radiol 2, 203–216 (1979). https://doi.org/10.1007/BF02552065

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02552065

Keywords

Search

Navigation