International Urology and Nephrology

, Volume 29, Issue 1, pp 25–31 | Cite as

Correlation of nuclear p53 over-expression with clinical and histopathological features of transitional cell bladder cancer

  • Z. Sinik
  • T. Alkibay
  • Ö. Ataoĝlu
  • G. Akyol
  • H. Tokuçoĝlu
  • I. Bozkirli


Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically with DO7 monoclonal antibody to detect over-expression of mutant p 53 gene. The findings were interpreted by correlating with patient age, sex, cigarette smoking, number and macroscopic appearance of tumour, histological tumour grade, muscular invasion, vascular invasion, necrosis and urothelial atypia or dysplasia. Mutant p53 gene was over-expressed in 8 (18.2%) specimens. Statistically significant correlation with grdde, vascular invasion, necrosis and patient sex was found with p53 over-expression. Available follow-up data were insufficient to draw a conclusion about the prognostic role of p53 over-expression. Prospective studies with larger number of patients are needed to define the exact place of nuclear p53 over-expression in transitional cell bladder cancer.


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Copyright information

© Akadémiai Kiadó 1997

Authors and Affiliations

  • Z. Sinik
    • 1
  • T. Alkibay
    • 1
  • Ö. Ataoĝlu
    • 2
  • G. Akyol
    • 2
  • H. Tokuçoĝlu
    • 1
  • I. Bozkirli
    • 1
  1. 1.Department of UrologyGazi University, School of MedicineAnkaraTurkey
  2. 2.Department of PathologyGazi University, School of MedicineAnkaraTurkey

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