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Influence of sex and chronic haemodialysis treatment on total, free and acyl carnitine concentrations in human serum

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Abstract

The influence of sex and haemodialysis treatment on serum total, free and acyl carnitine concentrations in healthy controls and chronic renal failure patients has been investigated. Patients on regular haemodialysis treatment generally displayed significantly decreased serum carnitine levels. The mean predialysis serum carnitine levels were not significantly different from the mean healthy control values. However, after dialysis a significant decrease in serum carnitine levels was observed compared to the predialysis and healthy control values. Moreover, serum ratio of acylated to free carnitine was significantly higher after haemodialysis, as compared to both healthy controls and predialysis patients. Sex-related changes in serum total, free and acyl carnitine levels and ratios of acylated to free carnitine have been observed in healthy controls and patients on chronic haemodialysis treatment.

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Authors and Affiliations

  1. Department of Biochemistry, King Saud University, College of Science, Riyadh

    A. S. Alhomida

  2. Department of Pathology, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia

    S. H. Sobki

  3. Department of Nephrology, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia

    M. H. Al-Sulaiman & A. A. Al-Khader

Authors
  1. A. S. Alhomida
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  2. S. H. Sobki
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  3. M. H. Al-Sulaiman
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  4. A. A. Al-Khader
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Alhomida, A.S., Sobki, S.H., Al-Sulaiman, M.H. et al. Influence of sex and chronic haemodialysis treatment on total, free and acyl carnitine concentrations in human serum. International Urology and Nephrology 29, 479–487 (1997). https://doi.org/10.1007/BF02551117

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  • DOI: https://doi.org/10.1007/BF02551117

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