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Tubular basement membrane thickening in diabetes mellitus

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Abstract

Authors measured the thickness of the basement membranes of the proximal and distal tubuli in the renal cortex in 20 patients with verified diabetes mellitus. The test group consisted of 20 patients with small abnormalities of glomeruli (or in the range of variable norm), of the same sex and comparable age. Measurements were performed in locations without tubulo-interstitial changes. The average thickness of TBM in patients with diabetes mellitus was 1540±616 nm, and in the test group 360±86 nm, which is a statistically significant difference (p<0.000000). In spite of the small number of cases and possible error in the manual measurement of electron microscopic pictures, a significant thickening of TBM in diabetes mellitus has been found. We consider this to be of diagnostic value.

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References

  1. Churg, J., Sobin, L. H.: Renal Disease. Classification and Atlas of Glomerular Diseases. Igaku-Shoin, Tokyo-New York 1982.

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  2. Slugeň, I., Biopsy in Glomerulonephritis and Relevant Processes (in Slovakian, with English summary). VEDA, Bratislava 1989.

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  3. Slugeň, I., Buček, J., Kováč, A., Slugeňová, E., Pauer, M., Fiala, P.: Diagnostic potentials of renal biopsy in diabetes mellitus (in Slovakian, with English summary).Vnitřní Lék, 37, 557 (1991).

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Authors and Affiliations

  1. Institute of Pathology, Derer's Hospital and Postgraduate Medical School, Bratislava, Slovak Republic

    D. Daniš, O. Nyitrayová & I. Slugeň

  2. 1st Department of Internal Medicine, Derer's Hospital and Postgraduate Medical School, Bratislava, Slovak Republic

    A. Kováč

  3. Department of Immunology, Institute of Preventive and Clinical Medicine, Educational Bases of the Postgraduate Medical School, Slovak Republic

    Š. Nyulassy

  4. Department of Internal Medicine, Hospital in Nitra, Slovak Republic

    A. Orban

Authors
  1. D. Daniš
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  2. O. Nyitrayová
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  3. I. Slugeň
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  4. A. Kováč
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  5. Š. Nyulassy
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  6. A. Orban
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Daniš, D., Nyitrayová, O., Slugeň, I. et al. Tubular basement membrane thickening in diabetes mellitus. International Urology and Nephrology 28, 589–592 (1996). https://doi.org/10.1007/BF02550972

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  • DOI: https://doi.org/10.1007/BF02550972

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