Skip to main content
Log in

The effect of alternate-day low dose prednisolone on bone age in children with steroid dependent nephrotic syndrome

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Radius, ulna, short bones (RUS), carpal (CARP) bone age (BA), tibial corticodiaphyseal (C/D) ratio and trabecular aspect were assessed in 19 children with steroid dependent nephrotic syndrome and 15 age matched healthy children. Both RUS and CARP BA were significantly lower than in the controls. Trabecular aspect and tibial C/D ratio did not show any statistical significance. There was a positive correlation between HSDS and RUS BA delay (r=−0.476, p<0.05); CARP BA delay and RUS BA delay (r=0.563, p<0.01) and RUS BA and CARP BA (r=0.891, p<0.001). In conclusion, RUS and CARP BA are both retarded and positively correlated in steroid dependent nephrotic children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Tanner, J. M., Whitehouse, R. H., Marshall, W. A., Healey, M. J. R., Goldstein, H.: Assessment of Skeletal Maturity and Prediction of Adult Height (TW2 method). Academic Press, London 1975.

    Google Scholar 

  2. Cundall, D. B., Brocklebank, J. T., Buckler, J. M. H.: Which bone age in chronic renal insufficiency and end-stage renal disease?Pediatr. Nephrol., 2, 200 (1988).

    Article  PubMed  CAS  Google Scholar 

  3. Polito, C., Greco, N., Opallo, A., Cimmaruta, E., La Manna, A.: Alternate-day steroids affect carpal maturation more than radius, ulna and short bones.Pediatr. Nephrol., 8, 480 (1994).

    Article  PubMed  CAS  Google Scholar 

  4. Blodgett, F. M., Burgin, L., Iezzonni, D., Gribetz, D., Talbot, N. B.: Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children.N. Engl. J. Med., 254, 636 (1956).

    Article  PubMed  CAS  Google Scholar 

  5. Soyka, L. F., Saxena, K. M. Alternate-day steroid therapy for nephrotic children.JAMA, 192, 225 (1965).

    PubMed  CAS  Google Scholar 

  6. Sadeghi-Nejad, A., Senior, B.: Adrenal function, growth, and insulin in patients treated with corticoids on alternate days.Pediatrics, 43, 277 (1969).

    PubMed  CAS  Google Scholar 

  7. Adhikari, M., Manikkam, N. E. G., Coovadia, H. M.: Effects of repeated courses of daily steroids and of persistent proteinuria on linear growth in children with nephrotic syndrome.Pediatr. Nephrol., 6, 4 (1992).

    Article  PubMed  CAS  Google Scholar 

  8. Foote, K. D., Brocklebank, J. T., Meadow, S. R.: Height attainment in children with steroid-responsive nephrotic syndrome.Lancet, 2, 917 (1985).

    Article  PubMed  CAS  Google Scholar 

  9. Polito, C., Oporto, M. R., Totino, S. F., La Manna, A., Di Toro, R.: Normal growth of nephrotic children during long-term alternate-day prednisone therapy.Acta Pediatr. Scand., 75, 245 (1986).

    CAS  Google Scholar 

  10. Polito, C., Di Toro, R.: Delayed pubertal growth spurt in glomerulopathic boys receiving alternate-day prednisone.Child. Nephrol. Urol., 12, 202 (1992).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bircan, Z., Soran, M., Yildirim, I. et al. The effect of alternate-day low dose prednisolone on bone age in children with steroid dependent nephrotic syndrome. International Urology and Nephrology 29, 357–361 (1997). https://doi.org/10.1007/BF02550936

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550936

Keywords

Navigation