Abstract
Forty-five patients who underwent transurethral resection (TUR) for Ta-Tl superficial bladder cancer were included in the study. Fourteen patients who had TUR alone were assigned to the control group. Epirubicin therapy was started two weeks after complete TUR of the tumour. Epirubicin in a dose of 50 mg diluted in 50 ml saline was instilled weekly for 8 weeks in the epirubicin group. The mean follow-up was 24 months.
Although recurrence rate was higher in the control group (64.2% versus 32.2%), it was not found to be statistically significant (p=0.0914, chi-square test). Tumour-free intervals in patients with recurrent disease were significantly longer in the epirubicin group (p<0.05, Mann-Whitney U-test).
In conclusion: intravesical epirubicin therapy, which both reduces recurrence rate and prolongs time to recurrence, was found to be effective in the prophylaxis of superficial bladder cancer.
Similar content being viewed by others
References
Silverberg, E., Boring, C. C., Squires, T. S.: Cancer statistics, 1990.CA, 40, 9 (1990).
Fitzpatrick, J. D., Reda, M.: Bladder carcinoma in patients 40 years old or less.J. Urol., 135, 53 (1986).
Fitzpatrick, J. M., West, A. B., Buttler, M. R., Lane, V., O'Flynn, J. D.: Superficial bladder tumors (stage pTa, grades 1 and 2): The importance of recurrence pattern following initial resection.J. Urol., 135, 920 (1986).
Van Der Meijden, A. P. M., Kurth, K., Oosterlinck, W., Debruyne, F. M. J. and Members of the EORTC Genito-Urinary Group: Intravesical therapy with Adriamycin and 4-epirubicin for superficial bladder sancer. The experience of the EORTC Group.Cancer Chemother. Pharmacol., 30 (Suppl.), 595 (1982).
Herr, H. W., Laudone, V. P., Whitmore, W. F. Jr.: An overview of intravesical therapy for superficial bladder tumors.J. Urol., 138, 1363 (1987).
Chai, M., Wientjes, M. G., Badalement, R. A., Burgers, J. K., Au, J. L. S.: Pharmacokinetics of intravesical doxorubicin in superficial bladder cancer patients.J. Urol., 152, 374 (1994).
Lutzeyer, W., Rubben, H., Dahm, H.: Prognostic parameters in superficial bladder cancer: An analysis of 315 cases.J. Urol., 127, 250 (1982).
Lundbeck, F., Pedersen, D., Stroyer, I., Uldall, A.: Absorption of doxorubicin hydrochloride during bladder washings in treatment of noninvasive bladder tumors.Urology, 18, 161 (1981).
Larson, A., Eksborg, S., Fritjoffson, A.: Intravesical instillation of adriamycin early after transurethral resection measurements of plasma levels.Eur. Urol., 10, 398 (1984).
Brantley, T., David, C.: Complications of intravesical chemotherapy.Urol. Clin. North. Am., 19, 529 (1992).
Melekos, M. D., Dauahauer, H., Fokaefs, E., Barbalias, G.: Intravesical instillations of 4-Epidoxorubicin (Epirubicin) in the prophylactic treatment of superficial bladder cancer: Results of a controlled prospective study.J. Urol., 147, 371 (1992).
Fernando, C. S., Fernando, F., Teixeira, B., Almedia, S.: 4-Epidoxorubicin versus mitomycin C intravesical chemoprophylaxis of superficial bladder cancer.Eur. Urol., 21, 42 (1992).
Burk, K., Kurt, K. H., Newling, D.: Epirubicin in treatment and recurrence prophylaxis of patients with superficial bladder cancer.Prog. Clin. Biol. Res., 303, 423 (1989).
Whelan, P., Cumming, J. A., Garvie, W. H. H., Hargreave, T. B., Kirk, D., Newling, D. W. W., Robinson, M. R. G., Smith, P. H.: Multi-centre Phase II study of low dose intravesical epirubicin in the treatment of superficial bladder cancer.Br. J. Urol., 67, 600 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Şengör, F., Beysel, M., Erdoĝan, K. et al. Intravesical epirubicin in the prophylaxis of superficial bladder cancer. International Urology and Nephrology 28, 201–206 (1996). https://doi.org/10.1007/BF02550861
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02550861