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Does the kind of immunosuppressive therapy influence plasma renin activity, aldosterone and vasopressin in patients with a kidney transplant?

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Abstract

In 24 patients with a functioning kidney transplant and in 33 healthy subjects plasma renin activity (PRA), plasma aldosterone and vasopressin (AVP) levels were assessed under basal conditions and after dietary sodium restriction. Twelve patients were treated with azathioprine and another 12 with cyclosporine A. From the results obtained it seems that immunosuppressive drugs used in transplanted patients are involved in the pathogenesis of endocrine abnormalities and that the kind of immunosuppressive therapy is of minor importance in their development or maintenance. Transplanted kidneys show a preserved reaction pattern of renin secretion to sodium deprivation and upright position.

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References

  1. Adu, D., Turney, J., Michael, J., McMaster, P.: Hyperkalaemia in cyclosporine-treated renal allograft recipients.Lancet, 2, 270 (1983).

    Google Scholar 

  2. Armitage, P.: Methods for the statistical assessment of medical investigations (in Polish). PZWL, Warszawa 1978.

    Google Scholar 

  3. Grzeszczak, W., Kokot, F., Dulawa, J.: Effects of naloxone administration on endocrine abnormalities in chronic renal failure.Am. J. Nephrol., 7, 93 (1987).

    Article  PubMed  CAS  Google Scholar 

  4. Kokot, F., Stupnicki, R.: Clinical application of radioimmunological and radiocompetitive methods (in Polish). PZWL, Warszawa 1985.

    Google Scholar 

  5. Literature on Sandimmun(e), Med. Doc. Basle. C. Mauric, 1 (1986).

  6. Myers, B. D., Ross, J., Newton, L., Luetscher, J., Perlroth, M.: Cyclosporine-associated chronic nephropathy.N. Engl. J. Med., 311, 699 (1984).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Silesian School of Medicine, Katowice, Poland

    T. Nieszporek, W. Grzeszczak, F. Kokot, E. Zukovska-Szczechowska & A. Wiecek

  2. Department of Surgery, Silesian School of Medicine, Katowice, Poland

    S. Kusmierski

  3. Department of Urology, Silesian School of Medicine, Katowice, Poland

    A. Szkodny

Authors
  1. T. Nieszporek
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  2. W. Grzeszczak
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  3. F. Kokot
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  4. E. Zukovska-Szczechowska
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  5. A. Wiecek
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  6. S. Kusmierski
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  7. A. Szkodny
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Additional information

This work was supported by the Polish Ministry of Health and Welfare, MZ XIII.

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Nieszporek, T., Grzeszczak, W., Kokot, F. et al. Does the kind of immunosuppressive therapy influence plasma renin activity, aldosterone and vasopressin in patients with a kidney transplant?. International Urology and Nephrology 21, 233–240 (1989). https://doi.org/10.1007/BF02550813

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  • DOI: https://doi.org/10.1007/BF02550813

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