Abstract
An association between nephropathy and malignant solid tumours or with lymphoproliferative disorders was repeatedly reported. This association is mainly manifested by a nephrotic syndrome. In Lee's study [14], 11% of the adult nephrotics whom they had seen over a ten-year period developed a carcinoma. Membranous glomerulonephritis (MGN) is the most common glomerular disease associated with malignant solid tumour; the association of membranoproliferative glomerulonephritis (MPGN) with solid tumour is still uncommon. Although lung carcinoma is relatively common, the incidence of glomerular involvement with this tumour is quite rare. To date, only a few cases of lung cancer associated with nephrotic syndrome or glomerulonephritis have been reported by various authors. MGN is the most common glomerular lesion associated with these cases; however, MPGN has not been reported to be associated with lung cancer before. We report on a 45-year old man with nephrotic syndrome due to MPGN which in this case seemed to be a component of the paraneoplastic syndrome.
Similar content being viewed by others
References
Norris, S. H.: Paraneoplastic glomerulopathies.Semin. Nephrol., 13, 258 (1993).
Pascal, R. R.: Renal manifestations of extrarenal neoplasms.Hum. Pathol., 11, 7 (1980).
Eagen, J. W., Lewis, E. J.: Glomerulopathies of neoplasia.Kidney Int., 11, 297 (1977).
Martinez-Maldonado, M., Baez-Diaz, L., Benabe, J. E.: Non-renal neoplasms and the kidney. In: Schrier, R., Gottschalk, C. W. (eds): Disease of the Kidney. Little, Brown, Boston 1988, pp. 2511–2532.
Hopper, J. Jr., Biava, C. B., Naughton, J. L.: Glomerular extracapillary proliferation (crescentic glomerulonephritis) associated with non-renal malignancies (Abstract).Kidney Int., 10, 544 (1976).
Whitworth, J. A., Morel-Marogel, L., Mignon, F., Richet, G.: The significance of extracapillary glomerulonephritis.Nephron, 16, 1 (1976).
Pascal, R. R., Finney, R. P., Rifkin, S. L., Kahana, L.: Glomerulonephritis and virus-like particles associated with prostatic cancer.Hum. Pathol., 11, 391 (1980).
Stuart, K., Fallon, B. G., Cardi, M. A.: Development of the nephrotic syndrome in a patient with prostatic carcinoma.Am. J. Med., 80, 295 (1986).
Haskell, L. P., Fusco, M. J., Wadler, S.: Crescentic glomerulonephritis associated with prostatic carcinoma: Evidence of immune mediated glomerular injury.Am. J. Med., 88, 189 (1990).
Donadio, J. W., Holley, K. E.: Membranoproliferative glomerulonephritis.Semin. Nephrol., 2, 214 (1982).
Bunn, P. A. Jr.: Lung cancer.Semin. Oncol., 15 (1), 318 (1988).
Richard-Mendes, D. A., Costa, C., Dupont, E., Hamers, H., Hooghe, R., Dupuis, E., Potvliege, R.: Nephrotic syndrome in bronchogenic carcinoma. Report of two cases with immunochemical studies.Clin. Nephrol., 2, 245 (1974).
Higgins, M. R., Randall, R. E., Still, W. J. S.: Nephrotic syndrome with oat-cell carcinoma.Br. Med. J., 3, 450 (1974).
Lee, J. R., Yamauchi, H., Hopper, J. Jr.: The association of cancer and nephrotic syndrome.Ann. Int. Med., 64, 41 (1966).
Morthy, A. V.: Minimal change glomerular disease: A paraneoplastic syndrome in two patients with bronchogenic carcinoma.Am. J. Kidney Dis., 3, 58 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Usalan, C., Emri, S. Membranoproliferative glomerulonephritis associated with small cell lung carcinoma. International Urology and Nephrology 30, 209–213 (1998). https://doi.org/10.1007/BF02550579
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02550579