Skip to main content
SpringerLink
Log in

Pericentric inversion of chromosome 9 in infertile men

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Reproductive condition was studied in 6 infertile men with pericentric inversion of chromosome 9. Semen analyses revealed one azoospermia, one oligozoospermia, three asthenozoospermias and one normozoospermia. Four cases showed normal levels of plasma gonadotropins and testosterone. The response of plasma testosterone to human chorionic gonadotropin was within the normal range in all cases. However, the administration of LH-RH resulted in abnormal response of plasma gonadotropin in all patients. These results indicate that infertile males with pericentric inversion of chromosome 9 have an abnormality in the hypothalamic-pituitary-testicular axis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Metaxotou, C., Kalpini-Mavrou, A., Panagou, M., Tsenghi, C.: Polymorphism of chromosome 9 in 600 Greek subjects.Am. J. Hum. Genet., 30, 85 (1978).

    PubMed  CAS  Google Scholar 

  2. Chandley, A. C.: Chromosomal basis of human infertility.Br. Med. Bull., 35, 181 (1979).

    PubMed  CAS  Google Scholar 

  3. Sasagawa, I., Nakada, T., Terada, T., Katayama, T.: Robertsonian translocation associated with azoospermia.Urol. Int., 44, 379 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. Takihara, H., Cosentine, M. J., Sakatoku, J., Cockett, A. T. K.: Significance of testicular size measurement in andrology. 2. Correlation of testicular size with testicular function.J. Urol., 137, 416 (1987).

    PubMed  CAS  Google Scholar 

  5. Sasagawa, I., Nakada, T., Kubota, Y., Sawamura, T., Ishigooka, M., Tateno, T., Tomaru, M.: Hormone profiles and testicular histology in cryptorchid boys with marker chromosome.Arch. Androl., 33, 105 (1994).

    PubMed  CAS  Google Scholar 

  6. Nielsen, J., Wohlert, M., Faaborg-Andersen, J., Hansen, K. B., Hvidman, L., Krag-Olsen, R., Moulvad, I., Videbach, P.: Incidence of chromosome abnormalities in newborn children. Comparison between incidence in 1969–1974 and 1980–1982 in same area.Hum. Genet., 61, 98 (1982).

    Article  PubMed  CAS  Google Scholar 

  7. Abyholm, T., Stray-Pedersen, S.: Hypospermatogenesis and chromosomal aberrations. A clinical study of azoospermic and oligozoospermic men with normal and abnormal karyotype.Int. J. Androl., 4, 546 (1981).

    PubMed  CAS  Google Scholar 

  8. Groupe de Cytogeneticiens Frances: Pericentric inversions in man. A French collaborate study.Ann. Genet., 29, 129 (1986).

    Google Scholar 

  9. Kaiser, P.: Pericentric inversions. Problems and significance for clinical genetics.Hum. Genet., 68, 1 (1984).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

    I. Sasagawa, M. Ishigooka, Y. Kubota, M. Tomaru, T. Hashimoto & T. Nakada

Authors
  1. I. Sasagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Ishigooka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Kubota
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Tomaru
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. Nakada
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sasagawa, I., Ishigooka, M., Kubota, Y. et al. Pericentric inversion of chromosome 9 in infertile men. International Urology and Nephrology 30, 203–207 (1998). https://doi.org/10.1007/BF02550578

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550578

Keywords

Search

Navigation