Skip to main content
SpringerLink
Log in

A new ancient irrigation therapy for childhood renal candidiasis

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Methylene blue (MB) alone, MB metabolites in the urine and the effect of MB plus alkalization on Candida species were determined. MB was used for the treatment of childhood renal candidiasis (CRC) in 3 patients as an irrigating solution. Besides irrigation, fluconazole 3 mg/kg/day intravenously and MB 0.2 mg/kg/day were administered perorally. Urine cultures were cleared of Candida. DMSA scans obtained after 6 months showed no evidence of scarring. MB can be used for irrigation of the urinary tract, with fewer side effects than amphotericin B (AB). Additionally we advocate the use of ureteral catheters instead of nephrostomy in the treatment of CRC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Amphotericin B inMicromedex, 1974–1995: 84: expires (30.6.1995).

  2. Bartone, F. F., Hurwitz, R. S., Rojas, E. L., Steinberg, E., Franceschini, R.: The role of percutaneous nephrostomy in the management of obstructing candidiasis of the urinary tract in infants.J. Urol., 140, 338 (1988).

    PubMed  CAS  Google Scholar 

  3. Cramer, B. C., Ozere, R., Andrews, W.: Renal stone formation following medical treatment of renal candidiasis.Pediatr. Radiol., 21, 43 (1990).

    Article  PubMed  CAS  Google Scholar 

  4. DiSanto, A., Wagner, J. G.: Pharmacokinetics of highly ionized drugs. II. Methylene blue. Absorption, metabolism and excretion in man and dog after oral administration.J. Pharm. Sci., 61, 1086 (1972).

    PubMed  CAS  Google Scholar 

  5. Eckstein, C. W., Kass, E. J.: Anuria in a newborn secondary to bilateral ureteropelvic fungus balls.J. Urol., 127, 109 (1982).

    PubMed  CAS  Google Scholar 

  6. Irby, P. B., Stoller, M. L., McAninch, J. W.: Fungal bezoars of the upper urinary tract.J. Urol., 143, 447 (1990).

    PubMed  CAS  Google Scholar 

  7. Joklik, W. K., Willet, H. P., Amos, D. B., Wilfert, C. M.: Sterilization and disinfection. In: Zinsser Microbiology, 20th ed. Chapt. 10. Appleton and Lange, U.S.A. 1992.

    Google Scholar 

  8. Matsumoto, A. H., Dejter, S. W., Barth, K. H., Gibbons, D. M. Percutaneous nephrostomy drainage in the management of neonatal anuria secondary to renal candidiasis.J. Pediatr. Surg., 12, 1295 (1990).

    Article  Google Scholar 

  9. Ortiz, O., Lee, W.: Percutaneous nephrostomy in the management of renal candidiasis.Arch. Surg., 124, 739 (1989).

    PubMed  CAS  Google Scholar 

  10. Rehan, V. K., Davidson, D. C.: Neonatal renal candidal bezoar.Arch. Dis. Child., 67, 63 (1992).

    Article  PubMed  CAS  Google Scholar 

  11. Reynolds, E. F. J.: Chelating agents, antidotes and antagonists: Methylene blue. In: Martindale, The Extra Pharmacopoeia, 29th ed. The Pharmaceutical Press, London 1989.

    Google Scholar 

  12. Robinson, P. J., Pocock, R. D., Frank, J. D.: The management of obstructive renal candidiasis in the neonate.Br. J. Urol., 59, 380 (1987).

    PubMed  CAS  Google Scholar 

  13. Scerpella, E. G., Alhalel, R.: An unusual cause of acute renal failure: Bilateral ureteral obstruction due to Candida tropicalis fungus balls.C.I.D., 18, 440 (1994).

    CAS  Google Scholar 

  14. Shadomy, S., Pfaller, M. A.: Laboratory studies with antifungal agents: Susceptibility tests and quantitation in body fluids. In: Balows, A., Havsler, W. J. (eds): Manual of Clinical Microbiology, 5th ed. American Society for Microbiology, Washington, D.C. 1991.

    Google Scholar 

  15. Smith, M. J.: Methylene blue in renal calculi. Results of five years study.Urology, 6, 676 (1975).

    Article  PubMed  CAS  Google Scholar 

  16. Smith, M. J. V.: Concretions and methylene blue.J. Urol., 107, 164 (1972).

    PubMed  CAS  Google Scholar 

  17. Stein, M., Eliahu, L., Bhupendra, M. T., Reid, R. E.: Unusual case of renal candidial fungus balls.Urology, 41, 49 (1993).

    Article  PubMed  CAS  Google Scholar 

  18. Şimşek, Ü., Akinci, H., Oktay, B., Kavrama, I., Özyurt, M.: Treatment of catheter-associated candiduria with fluconazole irrigation.Br. J. Urol., 75, (1995).

  19. Tacker, J. R.: Successful use of fluconazole for treatment of urinary tract fungal infections.J. Urol., 148, 1917 (1992).

    PubMed  CAS  Google Scholar 

  20. Wheeler, J. G., Boyle, R., Abramson, J.: Candida tropicalis pyelonephritis successfully treated with 5-fluorocytosine and surgery.J. Pediatr., 102, 627 (1983).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Surgery, Dokuz Eylül University, Medical Faculty, Izmir, Turkey

    T. Aktuĝ, M. Olguner, F. M. Akgür, C. Aldirmaz & M. Hoşgör

  2. Department of Microbiology, Dokuz Eylül University, Medical Faculty, Izmir, Turkey

    N. Yuluĝ

Authors
  1. T. Aktuĝ
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Olguner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. M. Akgür
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Aldirmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Hoşgör
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. Yuluĝ
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aktuĝ, T., Olguner, M., Akgür, F.M. et al. A new ancient irrigation therapy for childhood renal candidiasis. International Urology and Nephrology 30, 127–132 (1998). https://doi.org/10.1007/BF02550565

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550565

Keywords

Search

Navigation