Skip to main content
SpringerLink
Log in

Age-specific PSA reference ranges in a group of non-urologic patients

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Age-specific serum PSA reference ranges have recently been proposed to be more sensitive in young and more specific in elder patients. However, some conflicting results have been reported from different centers.

In order to establish age-specific PSA reference ranges for our country, we measured the serum PSA levels of 400 healthy men over 40, between February 1995 and June 1996. Our study population consisted of men who had either PSA values lower than 4.0 ng/ml and normal digital rectal examination or negative prostatic biopsies taken for any reason. IMX assay was used for PSA determination in all patients.

Mean PSA values and standard deviations for each age group were: 1.7±1.1 ng/ml for 40–49 years (n=28), 2.0±1.2 ng/ml for 50–59 years (n=110), 2.9±1.7 ng/ml for 60–69 years (n=158) and 3.5±2.0 ng/ml for 70–79 years (n=104).

We conclude that further studies of larger series will lead us to standardize age-specific reference ranges in our country and, accordingly, we will be able to select the candidates for prostate biopsy more adequately.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rommel, F. M., Agusta, V. E., Breslin, J. A., Huffnagle, H. W., Pohl, C. E., Sieber, P. R., Stahl, C. A.: The use of prostate specific antigen and prostate specific antigen density in the diagnosis of prostate cancer in a community based urology practice.J. Urol., 151, 88 (1994).

    PubMed  CAS  Google Scholar 

  2. Ablin, R. J., Soanes, W. A., Bronson, P.: Precipitating antigens of the normal human prostate.J. Reprod. Fertil, 22, 573 (1970).

    Article  PubMed  CAS  Google Scholar 

  3. Hara, M., Koyonagi, Y., Inoue, T., Fukuyara, T.: Some physiochemical characteristics of gamma seminoprotein, and antigenic component specific for human seminal plasma. Forensic immunological study of body fluids and secretions.Jap. J. Legal Med., 25, 322 (1971).

    CAS  Google Scholar 

  4. Kuriyama, M., Wang, M. C., Pepsidore, L. D., Killian, C. S., Murphy, G. P.: Quantitation of prostate-specific antigen in serum by a sensitive enzyme immunoassay.Cancer Res., 40, 4658 (1980).

    PubMed  CAS  Google Scholar 

  5. Chan, D. W., Bruzek, D. J., Oesterling, J. E., Rock, R. C., Wals, P. S.: Prostate specific antigen as a marker for prostate cancer: A monoclonal and a polyclonal immunoassay compared.Clin. Chem., 33, 1916 (1987).

    PubMed  CAS  Google Scholar 

  6. Oesterling, J. E., Chan, D. W., Epstein, J. I., Kimball, A. W., Brendler, C. B., Walsh, P. C.: Prostate specific antigen in the preoperative and postoperative evaluation of localized prostatic cancer treated with radical prostatectomy.J. Urol., 139, 766 (1988).

    PubMed  CAS  Google Scholar 

  7. Yuan, J. J. J., Coplen, D. E., Petro, J. A., Figenshau, R. S., Ratliff, T. L., Catalona, W. F.: Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum prostate specific antigen levels. Part 2.J. Urol., 147, 810 (1992).

    PubMed  CAS  Google Scholar 

  8. Pearson, J. D., Carter, H. B.: Natural history of changes in prostate specific antigen in early stage prostate cancer.J. Urol., 152, 1743 (1994).

    PubMed  CAS  Google Scholar 

  9. Stamey, T. A., Yang, N., Anderson, K., Redwinw, E.: Prostate specific antigen as a serum marker for adenocarcinoma of the prostate.N. Engl. J. Med., 317, 909 (1987).

    Article  PubMed  CAS  Google Scholar 

  10. Partin, A. W., Carter, H. B., Chan, D. W., Rock, R. C., Walls, P. C.: Prostate specific antigen in the staging of localized prostate cancer: Influence of tumor differentiation, tumor volume and benign hyperplasia.J. Urol., 143, 747 (1990).

    PubMed  CAS  Google Scholar 

  11. Hudson, M. A., Bahnson, R. R., Catalona, W. J.: Clinical use of prostate specific antigen in patients with prostate cancer.J. Urol., 142, 1011 (1989).

    PubMed  CAS  Google Scholar 

  12. Ruckle, H. C., Klee, G. G., Oesterling, J. E.: Prostate specific antigen: Critical issues for the practicing physician.Mayo Clin. Proc., 69, 59 (1994).

    PubMed  CAS  Google Scholar 

  13. Oesterling, J. E., Chute, C. G., Jacobsen, S. J., Johnson, C. L., Lieber, M. M.: Longitudinal changes in serum PSA in a community-based cohort of men. Part 2.J. Urol., 149, 412 (1993).

    Google Scholar 

  14. Oesterling, J. E., Jacobsen, S. F., Chute, C. G., Guess, H. A., Lieber, M. M.: Serum prostate specific antigen in a community based population of healthy men. Establishment of age-specific reference ranges.J.A.M.A., 270, 860 (1993).

    Article  PubMed  CAS  Google Scholar 

  15. Dalkin, B. L., Ahmann, F., Southwick, P., Bottachini, M. R.: Derivation of normal prostate specific atigen levels by age. Part 2.J. Urol., 149, 413. Abstract 803 (1993).

    Google Scholar 

  16. Riċhie, J. P., Catalona, W. J., Ahmann, F. R., Scardino, P. T., Southwick, P. C.: Effect of patient age on early detection of prostate cancer with serum prostate specific antigen and digital rectal examination.Urology, 42, 365 (1993).

    Article  PubMed  Google Scholar 

  17. Catalona, W. J., Hudson, M. A., Scardino, P. T., Richie, J. P., Southwick, P. C.: Selection of optimal prostate cancer: Receiver operating characteristic curves.J. Urol., 152, 2037 (1994).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Şişly Etfal General Hospital, Istanbul, Turkey

    A. C. Atalay, M. I. Karaman, S. Güney, A. Dalkiliç, A. Y. Müslümanoĝlu & E. Ergenekon

Authors
  1. A. C. Atalay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. I. Karaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Güney
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Dalkiliç
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Y. Müslümanoĝlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Ergenekon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atalay, A.C., Karaman, M.I., Güney, S. et al. Age-specific PSA reference ranges in a group of non-urologic patients. International Urology and Nephrology 30, 587–591 (1998). https://doi.org/10.1007/BF02550550

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550550

Keywords

Search

Navigation